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      Comparison of the Immediate Effects of Two Beta-Blocking Drugs: A Nonselective and a Cardioselective with Modest ISA in Exercise-Induced Angina

      , , ,

      Cardiology

      S. Karger AG

      Visacor, Angina pectoris

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          Abstract

          To compare the effects of two beta-blocking drugs: a nonselective (propranolol) and a cardioselective with modest intrinsic sympathomimetic activity (visacor), 24 patients with stable angina pectoris performed a control exercise (without medication) on a bicycle ergometer (increments of 30 W every 3 min), and thereafter were randomized to receive either propranolol (40 mg t.i.d.) or visacor (200 mg once daily) for a 48-hour double-blind trial. The 2 groups on control exercise were similar with regard to their exercise tolerance: 7.6 ± 2.3 versus 7.1 ± 1.4 min (NS) and the behavior of heart rate, systolic, diastolic blood pressure and double product, at rest and during exercise. They exercised on the 2nd day 2 h after the intake of propranolol or visacor. In the 12 patients randomized to propranolol, heart rate, systolic and diastolic pressures, double product were significantly reduced at rest, compared with control exercise: 67 ± 8 versus 81 ± 10 beats/min (p < 0.01), 132 ± 20 versus 146 ± 21 mm Hg (p < 0.02), 80 ± 8 versus 88 ± 10 mm Hg (p < 0.02), 8,828 ± 1,927 versus 11,863 ± 2,138 mm Hg·min-<sup>1</sup> (p < 0.001), respectively. On the contrary, in the 12 patients randomized to visacor, these parameters at rest were less modified and only heart rate was significantly decreased: 71 ± 9 versus 81 ± 11 beats/min (p < 0.05). The onset of ST-segment depression (≧ 1.0 mm) was delayed 14% (p < 0.05) in the propranolol group, and 31 % (p < 0.01) in the visacor group. The peak double product decreased 27% (p < 0.001) in the propranolol group and 17% (p < 0.02) in the visacor group. Both drugs increased exercise duration, but only in the visacor group, the changes were significant (17%, p < 0.02, vs. 5%, NS in propranolol group). In conclusion, visacor seems to be at least as efficient as propranolol in exercise-induced angina.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1987
          1987
          11 November 2008
          : 74
          : 1
          : 43-48
          Affiliations
          Hôpital Erasme, Medical Cardiology Department, Université Libre de Bruxelles, Belgium
          Article
          174173 Cardiology 1987;74:43–48
          10.1159/000174173
          2880663
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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