Angiotensin II Effects upon Glomerular Intracapillary Volume in the Rat

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Abstract

The direct action of angiotensin II on renal glomeruli was quantified by measuring extracellular space in isolated, decapsulated rat glomeruli using <sup>14</sup>C-inulin. The glomerular inulin space significantly decreased when treated with 0.1 n M to 1 µ M of angiotensin II. The decrease was dose-dependent and blocked by 1-Sar, 8-Ile angiotensin II. Since the glomerular intracapillary space seems to occupy the majority of the extracellular (inulin) space in decapsulated glomeruli, these results suggest that angiotensin II decreases the glomerular intracapillary volume. This action of angiotensin II may lead to a reduction in glomerular filtering surface area, and thus, in the ultrafiltration coefficient.

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Journal

Journal ID (publisher-id): KBR

Journal ID (nlm-ta): Kidney Blood Press Res

Journal ID (doi): 10.1159/issn.1420-4096

Title: Kidney and Blood Pressure Research

Publisher: S. Karger AG

ISSN (Print): 1420-4096

ISSN (Electronic): 1423-0143

Publication date Subscription-year: 1984

Publication date (Print): 1984

Publication date (Electronic): 07 November 2008

Volume: 7

Issue: 6

Pages: 344-348

Affiliations

The Third Department of Medicine, Shiga University of Medical Science, Seta, Ohtsu, Shiga, Japan

Article

Publisher ID: 172956 Other ID: Renal Physiol 1984;7:344–348

DOI: 10.1159/000172956

PubMed ID: 6505372

SO-VID: c75a97a2-6180-47d8-9809-204bb81c243b

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 19 January 1984

Page count

Pages: 5

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