+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      A Mathematical Model to Assess Changes in the Baroreceptor Reflex

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          A mathematical model relating carotid sinus pressure (CSP) to systemic arterial pressure (SAP) explains the relationship between CSP and SAP with an accuracy of 96 %. The 4 parameters of the model are all physiologically meaningful. They include: the total range of control of SAP (identified as A(l), in mm Hg); the sensitivity of the reflex response (identified as A(2), in mm Hg<sup>-1</sup>); the carotid sinus pressure from which equal pressor and depressor responses may be elicited (identified as A(3), in mm Hg), and the lower limit to which SAP may be driven by maximal carotid sinus stimulation (identified as A(4), in mm Hg). Several other physiologically meaningful parameters can be calculated from the model, e.g. threshold, saturation, and set point for carotid sinus pressures. Experimental interventions are shown to effect changes in parameters, and these changes can be used to analyze alterations in the reflex response. For example, from the elevated gain, A(2), of the reflex response after vagotomy it can be deduced that the aortic baroreceptors have a damping effect on the carotid sinus reflex response.

          Related collections

          Author and article information

          S. Karger AG
          29 October 2008
          : 57
          : 5
          : 295-310
          Departments of Physiology and Biometry, Emory University, Atlanta, Ga.
          169528 Cardiology 1972;57:295–310
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 16


          Comment on this article