Apical ballooning syndrome (ABS) is a unique transient cardiomyopathy that mimics
an acute myocardial infarction. The relative frequency of ST-segment elevation on
the 12-lead electrocardiogram (ECG) and its prognostic significance is unknown. The
aims of this study were to evaluate the frequency and the clinical correlates of ST-
and T-wave abnormalities on the admission ECG in patients with ABS.
Patients were retrospectively identified from the cardiac catheterization database--those
who underwent coronary and left ventricular angiography and fulfilled the Mayo criteria
for ABS during the period January 1988 to November 2006. They were divided into 3
groups according to the presence of (1) ST-segment elevation (>1 mm in 2 contiguous
lead) or new left bundle branch block, (2) T-wave inversion (>3 mm in 3 contiguous
leads) but no ST shift, and (3) nonspecific ST-T abnormalities or normal ECG at the
time of admission. Clinical and echocardiographic findings were compared between groups.
Among the 105 patients, 36 (34.2%), 32 (30.4%), and 37 (35.2%) patients were in the
three respective groups. There were no differences in the clinical characteristics,
ejection fraction, and outcomes between the 3 groups. Over a median follow-up of 2.5
years, there was no difference in the 5-year recurrence rate of ABS between the 3
groups (13%, 5%, 17% patients, respectively, P = .25). The 5-year mortality was similar
in the 3 groups (24%, 7.3%, 10.8%, P = .58).
ST-segment elevation is absent in two thirds of patients with ABS. Thus, the cardiomyopathy
may mimic either ST-elevation or non-ST-elevation myocardial infarction. The ECG abnormalities
at presentation do not correlate with the magnitude of ventricular dysfunction or