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      Mucosal Immunity in Adult Primary Glomerulonephritis

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          Abstract

          Salivary components (proteins, albumin, IgA1, IgA2, IgG, IgM, β<sub>2</sub>-microglobulin, neopterin and peroxidase) were investigated in 3 adult types of primary glomerulonephritis (PGN): IgA mesangial glomerulonephritis (IgAGN; n = 14); idiopathic membranous glomerulonephritis (n = 8); idiopathic nephrotic syndrome (INS; n = 14), and a control group (n = 11). Salivary IgAl levels were significantly increased in all these PGN whereas salivary IgA2 levels were only higher than controls in INS. Albumin and proteins did not differ between PGN and controls, while the IgAl + IgA2/protein ratio was significantly increased in these 3 PGN. Salivary neopterin levels were enhanced in the 3 types of PGN, whereas β<sub>2</sub>-microglobulin levels were not. The other salivary components did not differ from controls. These results demonstrate the nonspecificity of the IgA increase at mucosal sites previously found in IgAGN and raise the hypothesis of an activation of mucosal immunity of PGN or of a disturbed isotypic network or lymphokine secretion in these diseases.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1990
          1990
          10 December 2008
          : 54
          : 1
          : 42-46
          Affiliations
          aDepartment of Nephrology, INSERM U 139, Centre Claude Bernard, Hôpital Henri Mondor, Créteil; bDepartment of Biochemistry, Paris VII, University of Paris, France
          Article
          185808 Nephron 1990;54:42–46
          10.1159/000185808
          2296344
          © 1990 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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