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      Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening.

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          Abstract

          Improved model systems to predict drug efficacy, interactions, and drug-induced kidney injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a suitable in vitro system because it reproduces the 3D microenvironment. A kidney-on-a-chip can mimic the structural, mechanical, transport, absorptive, and physiological properties of the human kidney. In this review we address the application of state-of-the-art microfluidic culturing techniques, with a focus on culturing kidney proximal tubules, that are promising for the detection of biomarkers that predict drug interactions and DIKI. We also discuss high-throughput screening and the challenges for in vitro to in vivo extrapolation (IVIVE) that will need to be overcome for successful implementation.

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          Author and article information

          Journal
          Trends Biotechnol.
          Trends in biotechnology
          1879-3096
          0167-7799
          Feb 2016
          : 34
          : 2
          Affiliations
          [1 ] Department of Pharmacology and Toxicology, Radboudumc, PO Box 9101, Nijmegen, HB 6500 The Netherlands. Electronic address: martijn.wilmer@radboudumc.nl.
          [2 ] MIMETAS BV, JH Oortweg 19, Leiden, CH, 2333 The Netherlands.
          [3 ] University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Gründenstrasse 40, 4132 Muttenz, Switzerland.
          [4 ] Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, Utrecht, CG 3584 The Netherlands.
          Article
          S0167-7799(15)00229-2
          10.1016/j.tibtech.2015.11.001
          26708346
          Copyright © 2015 Elsevier Ltd. All rights reserved.

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