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      Authors - did you know SICOT-J has been awarded the DOAJ Seal for "best practice in open access publishing"?

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      Osteosarcoma: a comprehensive review

      review-article
      Author(s): 1 , 1 , 1 , 2 , 1 , *
      Publication date (Electronic, collection):
      Publication date (Electronic, pub):
      Journal: SICOT-J
      Publisher: EDP Sciences
      Keywords: Osteosarcoma, Review, Oncology, Sarcoma, Tumor

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          Abstract

          Osteosarcoma (OS) is a relatively rare tumor of bone with a worldwide incidence of 3.4 cases per million people per year. For most of the twentieth century, five-year survival rates for classic OS were very low. In the 1970s, the introduction of adjuvant chemotherapy in the treatment of OS increased survival rates dramatically. The current article reviews the various types of OS and analyzes the clinical and histological features. We also examine historical and current literature to present a succinct review of methods for diagnosis and staging, as well as treatment, and we also discuss some of the future directions of treatment.

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          Osteosarcoma: anatomic and histologic variants.

          Michael Klein, Gene P. Siegal (2006)
          Osteosarcoma is the most common primary tumor of bone, yet its absolute incidence among malignant tumors is low. Within its strict histologic definition, osteosarcoma comprises a family of lesions with considerable diversity in histologic features and grade. Its prognosis is dependent not only on these parameters, but also on its anatomic site. It may occur inside the bones (in the intramedullary or intracortical compartment), on the surfaces of bones, and in extraosseous sites. Information of diagnostic or prognostic significance has not been elucidated from studies of its cytogenetics. This review summarizes the anatomic and histologic variations of osteosarcoma and offers a schema for its subclassification.
          Article 0 comments Cited 82 times – based on 0 reviews     Review now
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            Immunotherapy with a HER2-Targeting Listeria Induces HER2-Specific Immunity and Demonstrates Potential Therapeutic Effects in a Phase I Trial in Canine Osteosarcoma.

            Nicola Mason, Josephine Gnanandarajah, Julie B Engiles … (2016)
            Recombinant Listeria vaccines induce tumor-specific T-cell responses that eliminate established tumors and prevent metastatic disease in murine cancer models. We used dogs with HER2/neu(+) appendicular osteosarcoma, a well-recognized spontaneous model for pediatric osteosarcoma, to determine whether a highly attenuated, recombinant Listeria monocytogenes expressing a chimeric human HER2/neu fusion protein (ADXS31-164) could safely induce HER2/neu-specific immunity and prevent metastatic disease.
            Article 0 comments Cited 70 times – based on 0 reviews     Review now
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              Aneurysmal bone cyst: concept, controversy, clinical presentation, and imaging.

              M J Kransdorf, D. Sweet (1995)
              The aneurysmal bone cyst is the result of a specific pathophysiologic change, which is probably the result of trauma or a tumor-induced anomalous vascular process. In approximately one third of cases, the preexisting lesion can be clearly identified. The most common of these is the giant cell tumor, which accounts for 19-39% of cases in which the preceding lesion is found. Other common precursor lesions include osteoblastoma, angioma, and chondroblastoma. Less common lesions include fibrous dysplasia, fibroxanthoma (nonossifying fibroma), chondromyxoid fibroma, solitary bone cyst, fibrous histiocytoma, eosinophilic granuloma, and even osteosarcoma. Interestingly, some of the controversy surrounding this lesion may be the result of a change in how the lesion was defined by Lichtenstein in 1953, when intramedullary lesions were added to the previously described juxtacortical (superficial) lesions. Members of the AFIP have suggested that many of the intramedullary lesions in which no previous lesion can be identified may represent giant cell tumors of bone. Their similarity to proved giant cell tumors in skeletally immature patients can be striking and seems more than coincidental. Appropriate treatment of an aneurysmal bone cyst requires the realization that it results from a specific pathophysiologic process, and identification of the preexisting lesion, if possible, is essential. Clearly an osteosarcoma with superimposed secondary aneurysmal bone cyst change must be treated as an osteosarcoma, and giant cell tumor with secondary features of aneurysmal bone cyst would be expected to be more likely to recur locally. The vast majority (approximately 80%) of patients presenting with aneurysmal bone cystlike findings are less than 20 years old. More than half of all such lesions occur in long bones, with approximately 12-30% of cases occurring in the spine. The pelvis accounts for about half of all flat bone lesions. Most patients present with pain and/or swelling, with symptoms usually present for less than 6 months. The imaging appearance of aneurysmal bone cyst reflects the underlying pathophysiologic change. Radiographs show an eccentric, lytic lesion with an expanded, remodeled "blown-out" or "ballooned" bony contour of the host bone, frequently with a delicate trabeculated appearance. Radiographs may rarely show flocculent densities within the lesion, which may mimic chondroid matrix. CT scanning will define the lesion and is especially valuable for those lesions located in areas in which the bony anatomy is complex, and which are not adequately evaluated by plain films. Fluid-fluid levels are common and may be seen on CT scans and MR images.(ABSTRACT TRUNCATED AT 250 WORDS)
              Article 0 comments Cited 69 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): SICOT J
                Journal ID (iso-abbrev): SICOT J
                Journal ID (publisher-id): sicotj
                Title: SICOT-J
                Publisher: EDP Sciences
                ISSN (Electronic): 2426-8887
                Publication date (Electronic, collection): 2018
                Publication date (Electronic, pub): 09 April 2018
                Volume: 4
                Issue: ( publisher-idID: sicotj/2018/01 )
                Electronic Location Identifier: 12
                Affiliations
                [1 ] Department of Orthopaedic Surgery, University of California San Diego San Diego CA USA
                [2 ] School of Medicine, University of Jeddah Jeddah Saudi Arabia
                Author notes
                [* ]Corresponding author: akulidjian@ 123456gmail.com
                Article
                Publisher ID: sicotj170018 Other ID: 10.1051/sicotj/2017028
                DOI: 10.1051/sicotj/2017028
                PMC ID: 5890448
                PubMed ID: 29629690
                SO-VID: c7a36f9c-3b31-4a57-aa20-d4648f59fd42
                Copyright © © The Authors, published by EDP Sciences, 2018
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 20 January 2017
                Date accepted : 15 April 2017
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 87, Pages: 8
                Categories
                Subject: Lower Limb
                Subject: Special Issue: "Musculoskeletal tumors: Current approaches and controversies" Guest Editor: A. Kulidjian
                Subject: Review Article

                Keywords: osteosarcoma,review,oncology,sarcoma,tumor
                Data availability:
                Keywords: osteosarcoma, review, oncology, sarcoma, tumor

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