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      Association between NRAMP1 gene polymorphism and multidrug-resistant tuberculosis in Han nationality of Yunnan

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          Abstract

          Objective To explore the relationship between NRAMP1 gene 3´UTR single nucleotide polymorphism and MDR-resistant tuberculosis in Yunnan Han population, and to find out the influencing factors of NRAMP1 genotype.

          Methods Polymorphism of NRAMP1 gene at 3´UTR was detected by PCR, the distribution and allele frequency difference of NRAMP1 gene 3´UTR genotypes were compared in the tuberculosis group (MDR-TB patients) and the control group (health examination population), and influencing factors of NRAMP1 genotype were analyzed by two-class logistic regression analysis of genotypes in tuberculosis group.

          Results The distribution frequencies of TGTG+/+ at 3´UTR locus of NRAMP1 gene were 60.7%/71.3% in tuberculosis group ( n=300) and control group( n=300), respectively. The distribution frequencies of TGTG +/+- were 33.0%/24.7% in tuberculosis group and control group, respectively. The distribution frequencies of TGTG-/- were 6.3%/ 4.0% in tuberculosis group and control group, respectively (χ 2=7.779, P=0.020). The genotype TGTG +/- and allele TGTG- increased susceptibility to MDR-PTB ( OR: 1.573, 95% CI: 1.097-2.255; OR: 1.516, 95% CI: 1.136-2.022). In logistic regression analysis, compliance ( OR=3.919, 95% CI=1.071-14.343), adverse drug reactions ( OR=0.212, 95% CI=0.062-0.728) and tuberculous pleurisy ( OR=0.159, 95% CI=0.049-0.523)were the three factors influencing the allele TGTG-.

          Conclusion TGTG - at 3´UTR locus of NRAMP1 gene is associated with MDR-PTB in Yunnan Han population. TGTG - is affected by compliance, adverse drug reactions and tuberculous pleurisy.

          Abstract

          摘要: 目的 探讨云南地区汉族人群 NRAMP1基因3´UTR位点单核苷酸多态性与耐多药肺结核发生的关系,并寻找基因型的影响因素。 方法应用聚合酶链式反应检测 NRAMP1基因3´UTR位点的多态性,比较感染组(耐多药肺结核患者)与对照组(健康体检人群)基因型的分布频率和等位基因的频率差异,并对感染组基因型的影响因素进行二分类logistic回归分析。 结果300例感染组与300例对照组 NRAMP1基因3´UTR位点的基因型TGTG+/+分布频率为60.7%/71.3%,基因型TGTG+/-分布频率为33.0%/24.7%,基因型TGTG-/-分布频率6.3%/4.0%,两组比较χ 2=7.779, P=0.020。基因型TGTG+/-增加了耐多药肺结核的易感性( OR:1.573,95% CI:1.097~2.255),等位基因TGTG-亦增加了其的易感性( OR:1.516,95% CI:1.136~2.022)。在影响因素分析中,患者的依从性( OR=3.919,95% CI=1.071~14.343)、药物的不良反应( OR=0.212,95% CI=0.062~0.728)、合并结核性胸膜炎( OR=0.159,95% CI=0.049~0.523)是等位基因TGTG缺失的影响因素。 结论云南汉族人群耐多药肺结核的发生与 NRAMP1基因3´UTR位点的TGTG缺失有关,而TGTG缺失又与患者的依从性、药物不良反应、合并结核性胸膜炎有关。

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          Author and article information

          Journal
          CTM
          China Tropical Medicine
          China Tropical Medicine (China )
          1009-9727
          01 January 2020
          01 March 2020
          : 20
          : 1
          : 13-17
          Affiliations
          1The Third People’s Hospital of Kunming City, Kunming, Yunnan 650041, China
          Author notes
          Corresponding author: SUN Hui, E-mail: 254914514@ 123456qq.com
          Article
          j.cnki.46-1064/r.2020.01.03
          10.13604/j.cnki.46-1064/r.2020.01.03
          © 2020 Editorial Department of China Tropical Medicine

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

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