Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity.

Jacobsen, Helle J.; Poulsen, Thomas T.; Dahlman-höglund, Anna; Kjær, Ida; Koefoed, Klaus; Sen, Jette W; Weilguny, Dietmar; Bjerregaard, Bolette; Andersen, Christina R; Horak, Ivan D.; Pedersen, Mikkel W; Kragh, Michael; Lantto, Johan

doi:10.1158/1078-0432.CCR-14-3312

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Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity.

Author(s): Helle J Jacobsen ¹ , Thomas T Poulsen ¹ , Anna Dahlman ¹ , Ida Kjær ¹ , Klaus Koefoed ¹ , Jette W Sen ¹ , Dietmar Weilguny ¹ , Bolette Bjerregaard ¹ , Christina R Andersen ¹ , Ivan D Horak ¹ , Mikkel W Pedersen ¹ , Michael Kragh ¹ , Johan Lantto ²

Publication date (Electronic): Sep 15 2015

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

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Abstract

Accumulating evidence indicates a high degree of plasticity and compensatory signaling within the human epidermal growth factor receptor (HER) family, leading to resistance upon therapeutic intervention with HER family members.

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Journal ID (iso-abbrev): Clin. Cancer Res.

Title: Clinical cancer research : an official journal of the American Association for Cancer Research

ISSN: 1078-0432

ISSN (Print): 1078-0432

Publication date (Electronic): Sep 15 2015

Volume: 21

Issue: 18

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[1 ] Symphogen A/S, Ballerup, Denmark.

[2 ] Symphogen A/S, Ballerup, Denmark. jol@symphogen.com.

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Publisher Item ID: 1078-0432.CCR-14-3312

DOI: 10.1158/1078-0432.CCR-14-3312

PubMed ID: 25908781

SO-VID: c7c7c00e-7b98-45ec-9de7-b8aea3f56929

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Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity.

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