ATP Release from the Isolated Perfused Guinea Pig Heart in Response to Increased Flow

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Abstract

The Langendorff heart preparation was used to investigate the release of ATP from the guinea pig heart in response to increased coronary flow. The luciferin-luciferase firefly technique was used to determine levels of ATP in the perfusate. During periods of increased flow, ATP release was rapidly and significantly increased by at least tenfold the basal release. The pressure/flow ratio was reduced in increased-flow conditions suggesting that coronary vasodilatation had occurred. It is concluded that ATP release from the guinea pig heart is increased under raised-flow conditions. It is suggested that this ATP release induces coronary vasodilatation.

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Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1996

Publication date (Print): 1996

Publication date (Electronic): 24 September 2008

Volume: 33

Issue: 1

Pages: 1-4

Affiliations

Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, UK

Article

Publisher ID: 159125 Other ID: J Vasc Res 1996;33:1–4

DOI: 10.1159/000159125

PubMed ID: 8603121

SO-VID: c7e1bfec-9290-4115-8061-8035feccb004

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 26 April 1995

Date accepted : 04 September 1995

Page count

Pages: 4

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