Mitotic kinases and phosphatases cooperate to shape the right response.

Abstract

Kinases and phosphatases, two sides of the same coin; are they opposing forces that switch signals on and off or enzymes that work together to give the right type of response at the right time? It depends on how close you stand when you view the big picture. Up close and detailed, and you'll see individual phosphorylation sites as binary switches - lights being toggled on/off by antagonistic forces. Take a step back and multiple copies of the same light are being toggled, perhaps leading to a range of intensities, or a flickering pattern, lights flashing in unison or at random. It depends what the signal requires. Stand even further back, let the story unfold, and you'll see a dazzling multicolour array of different lights. A coordinated sequence of color that appears to burst into life at different times in different places, with a pace that is both frantic and serene. This is a vision of mitosis and what a true spectacle it is.