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      Experimental Urate Nephropathy: Studies of the Distribution of Urate in Renal Tissue

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      Nephron

      S. Karger AG

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          Abstract

          In an attempt to delineate factors responsible for the accumulation of uric acid in renal tissue in vivo, the concentration of urate in renal cortex, medulla and papilla was measured in dogs infused with varying amounts of lithium urate. During antidiuresis, urate concentration increased as the papilla was approached, and with large urate infusions, the concentration of urate in papillary tissue equalled or exceeded that in urine. Renal accumulation of urate was roughly proportional to the plasma level of urate, and was reduced by water loading or mannitol diuresis. Renal concentrating ability was not consistently altered by acute infusions of urate.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1964
          1964
          25 November 2008
          : 1
          : 3
          : 144-157
          Affiliations
          The Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn.
          Article
          179328 Nephron 1964;1:144–157
          10.1159/000179328
          14246792
          © 1964 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 14
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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