6
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Effects of Exercise-Induced Stress on Platelet Aggregation

      research-article
      ,
      Cardiology
      S. Karger AG
      Two-step Master’s test, Coronary artery disease, Myocardial infarction, Platelet aggregation

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In order to determine if the stress of a standard exercise test wil affect the propensity for platelets to aggregate, platelet aggregometer studies were performed before and after a double two-step Master’s test in 19 patients with angina and in 19 normal controls. The response of platelet-rich plasma to 0.1, 1 and 10 µMof ADP and 1 and 10 µMof epinephrine were tested in a Chrono-Log aggregometer. Prior to exercise there was no significant difference between the number of patients and controls responding with irreversible aggregation to any of the five tests. Immediately following exercise, no significant differences in the number of irreversible aggregation responses were seen in the control group. In the group with coronary artery disease, the incidence of irreversible responses was significantly higher after exercise on test with 1 µM ADP (p < 0.05), 1 µM epinephrine (p = 0.02), and 10 µM epinephrine (p < 0.05). It is concluded that exercise increases significantly the tendency of platelets to aggregate among patients with coronary artery disease. It is possible that this effect may play a role in myocardial infarction induced during stress.

          Related collections

          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1975
          1975
          29 October 2008
          : 60
          : 5
          : 304-314
          Affiliations
          Cardiac Section of the Bronx VA Hospital and Mount Sinai School of Medicine, New York, N.Y.
          Article
          169728 Cardiology 1975;60:304–314
          10.1159/000169728
          1231964
          c80fc99f-9511-4548-bb6b-484f20ef7097
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 11
          Categories
          Review

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Platelet aggregation,Myocardial infarction,Coronary artery disease,Two-step Master’s test

          Comments

          Comment on this article