Atypical frontoamygdala functional connectivity in youth with autism

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Abstract

Functional connectivity (FC) between the amygdala and the ventromedial prefrontal cortex underlies socio-emotional functioning, a core domain of impairment in autism spectrum disorder (ASD). Although frontoamygdala circuitry undergoes dynamic changes throughout development, little is known about age-related changes in frontoamygdala networks in ASD. Here we characterize frontoamygdala resting-state FC in a cross-sectional sample (ages 7–25) of 58 typically developing (TD) individuals and 53 individuals with ASD. Contrary to hypotheses, individuals with ASD did not show different age-related patterns of frontoamygdala FC compared with TD individuals. However, overall group differences in frontoamygdala FC were observed. Specifically, relative to TD individuals, individuals with ASD showed weaker frontoamygdala FC between the right basolateral (BL) amygdala and the rostral anterior cingulate cortex (rACC). These findings extend prior work to a broader developmental range in ASD, and indicate ASD-related differences in frontoamygdala FC that may underlie core socioemotional impairments in children and adolescents with ASD.

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Emotional processing in anterior cingulate and medial prefrontal cortex.

Amit Etkin, Tobias Egner, Raffael Kalisch (2011)

Negative emotional stimuli activate a broad network of brain regions, including the medial prefrontal (mPFC) and anterior cingulate (ACC) cortices. An early influential view dichotomized these regions into dorsal-caudal cognitive and ventral-rostral affective subdivisions. In this review, we examine a wealth of recent research on negative emotions in animals and humans, using the example of fear or anxiety, and conclude that, contrary to the traditional dichotomy, both subdivisions make key contributions to emotional processing. Specifically, dorsal-caudal regions of the ACC and mPFC are involved in appraisal and expression of negative emotion, whereas ventral-rostral portions of the ACC and mPFC have a regulatory role with respect to limbic regions involved in generating emotional responses. Moreover, this new framework is broadly consistent with emerging data on other negative and positive emotions. Published by Elsevier Ltd.

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An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data.

Theodore D. Satterthwaite, Mark A. Elliott, Raphael Gerraty … (2013)

Several recent reports in large, independent samples have demonstrated the influence of motion artifact on resting-state functional connectivity MRI (rsfc-MRI). Standard rsfc-MRI preprocessing typically includes regression of confounding signals and band-pass filtering. However, substantial heterogeneity exists in how these techniques are implemented across studies, and no prior study has examined the effect of differing approaches for the control of motion-induced artifacts. To better understand how in-scanner head motion affects rsfc-MRI data, we describe the spatial, temporal, and spectral characteristics of motion artifacts in a sample of 348 adolescents. Analyses utilize a novel approach for describing head motion on a voxelwise basis. Next, we systematically evaluate the efficacy of a range of confound regression and filtering techniques for the control of motion-induced artifacts. Results reveal that the effectiveness of preprocessing procedures on the control of motion is heterogeneous, and that improved preprocessing provides a substantial benefit beyond typical procedures. These results demonstrate that the effect of motion on rsfc-MRI can be substantially attenuated through improved preprocessing procedures, but not completely removed. Copyright © 2012 Elsevier Inc. All rights reserved.

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Neurobiology of emotion perception I: The neural basis of normal emotion perception.

Mary Phillips, Wayne C. Drevets, Scott L Rauch … (2003)

There is at present limited understanding of the neurobiological basis of the different processes underlying emotion perception. We have aimed to identify potential neural correlates of three processes suggested by appraisalist theories as important for emotion perception: 1) the identification of the emotional significance of a stimulus; 2) the production of an affective state in response to 1; and 3) the regulation of the affective state. In a critical review, we have examined findings from recent animal, human lesion, and functional neuroimaging studies. Findings from these studies indicate that these processes may be dependent upon the functioning of two neural systems: a ventral system, including the amygdala, insula, ventral striatum, and ventral regions of the anterior cingulate gyrus and prefrontal cortex, predominantly important for processes 1 and 2 and automatic regulation of emotional responses; and a dorsal system, including the hippocampus and dorsal regions of anterior cingulate gyrus and prefrontal cortex, predominantly important for process 3. We suggest that the extent to which a stimulus is identified as emotive and is associated with the production of an affective state may be dependent upon levels of activity within these two neural systems.

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Author and article information

Journal

Journal ID (nlm-journal-id): 101541838

Journal ID (pubmed-jr-id): 38415

Journal ID (nlm-ta): Dev Cogn Neurosci

Journal ID (iso-abbrev): Dev Cogn Neurosci

Title: Developmental cognitive neuroscience

ISSN (Print): 1878-9293

ISSN (Electronic): 1878-9307

Publication date Nihms-submitted: 7 June 2019

Publication date (Electronic): 07 December 2018

Publication date (Print): June 2019

Publication date PMC-release: 14 June 2019

Volume: 37

Page: 100603

Affiliations

[a ]Department of Psychology, Yale University, New Haven, CT 06511, USA

[b ]Department of Psychology, University of Miami, Coral Gables, FL 33124, USA

[c ]Division of Developmental Medicine, Harvard University, Boston, MA 02115, USA

[d ]Department of Psychology, Columbia University, New York, NY 10027, USA

[e ]Neuroscience Program, University of Miami Miller School of Medicine, Miami FL, 33136, USA

Author notes

[* ]Corresponding author at: Yale University, 2 Hillhouse Ave, New Haven, CT 06511, USA. paola.odriozola@ 123456yale.edu (P. Odriozola).

[1]

These two authors contributed equally to this work.

Article

Manuscript ID: NIHMS1530851

DOI: 10.1016/j.dcn.2018.12.001

PMC ID: 6570504

PubMed ID: 30581125

SO-VID: c830e744-0964-4669-9cc4-16e4458fc490

License:

This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/BY-NC-ND/4.0/).

Atypical frontoamygdala functional connectivity in youth with autism

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Abstract

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Most cited references 92

Emotional processing in anterior cingulate and medial prefrontal cortex.

An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data.

Neurobiology of emotion perception I: The neural basis of normal emotion perception.

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