A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems

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Abstract

Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal carriers, nanolipid dispersions (liposomes, deformable liposomes, virosomes, ethosomes, and solid lipid nanoparticles) are ideal delivery systems with the advantages of biodegradation and nontoxicity. Among them, nano-structured lipid carriers and solid lipid nanoparticles (SLNs) are dominant, which can be modified to exhibit various advantages, compared to liposomes and polymeric nanoparticles. Nano-structured lipid carriers and SLNs are non-biotoxic since they are biodegradable. Besides, they are highly stable. Their (nano-structured lipid carriers and SLNs) morphology, structural characteristics, ingredients used for preparation, techniques for their production, and characterization using various methods are discussed in this review. Also, although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage.

Abstract

Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed.

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Most cited references 11

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Drug Delivery Nanoparticles in Skin Cancers

Chiara Dianzani, Gian Zara, Giovanni Maina … (2014)

Nanotechnology involves the engineering of functional systems at nanoscale, thus being attractive for disciplines ranging from materials science to biomedicine. One of the most active research areas of the nanotechnology is nanomedicine, which applies nanotechnology to highly specific medical interventions for prevention, diagnosis, and treatment of diseases, including cancer disease. Over the past two decades, the rapid developments in nanotechnology have allowed the incorporation of multiple therapeutic, sensing, and targeting agents into nanoparticles, for detection, prevention, and treatment of cancer diseases. Nanoparticles offer many advantages as drug carrier systems since they can improve the solubility of poorly water-soluble drugs, modify pharmacokinetics, increase drug half-life by reducing immunogenicity, improve bioavailability, and diminish drug metabolism. They can also enable a tunable release of therapeutic compounds and the simultaneous delivery of two or more drugs for combination therapy. In this review, we discuss the recent advances in the use of different types of nanoparticles for systemic and topical drug delivery in the treatment of skin cancer. In particular, the progress in the treatment with nanocarriers of basal cell carcinoma, squamous cell carcinoma, and melanoma has been reported.

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Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases.

Howard Gendelman, Vellareddy Anantharam, Tatiana Bronich … (2015)

Interest in nanoneuromedicine has grown rapidly due to the immediate need for improved biomarkers and therapies for psychiatric, developmental, traumatic, inflammatory, infectious and degenerative nervous system disorders. These, in whole or in part, are a significant societal burden due to growth in numbers of affected people and in disease severity. Lost productivity of the patient and his or her caregiver, and the emotional and financial burden cannot be overstated. The need for improved health care, treatment and diagnostics is immediate. A means to such an end is nanotechnology. Indeed, recent developments of health-care enabling nanotechnologies and nanomedicines range from biomarker discovery including neuroimaging to therapeutic applications for degenerative, inflammatory and infectious disorders of the nervous system. This review focuses on the current and future potential of the field to positively affect clinical outcomes. From the clinical editor: Many nervous system disorders remain unresolved clinical problems. In many cases, drug agents simply cannot cross the blood-brain barrier (BBB) into the nervous system. The advent of nanomedicines can enhance the delivery of biologically active molecules for targeted therapy and imaging. This review focused on the use of nanotechnology for degenerative, inflammatory, and infectious diseases in the nervous system.

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Micelle-based activatable probe for in vivo near-infrared optical imaging of cancer biomolecules.

Isao Hara, Yoichi Shimizu, Masahiro Ono … (2013)

Near-infrared (NIR: 800-1000 nm) fluorescent probes, which activate their fluorescence following interaction with functional biomolecules, are desirable for noninvasive and sensitive tumor diagnosis due to minimal tissue interference. Focusing on bioavailability and applicability, we developed a probe with a self-assembling polymer micelle, a lactosome, encapsulating various quantities of NIR dye (IC7-1). We also conjugated anti-HER2 single chain antibodies to the lactosome surface and examined the probe's capacity to detect HER2 in cells and in vivo. Micelles encapsulating 20mol% IC7-1 (hIC7L) showed 30-fold higher fluorescence (λem: 858 nm) after micelle denaturation compared to aqueous buffer. Furthermore, antibody modification allowed specific activation of the probe (HER2-hIC7L) following internalization by HER2-positive cells, with the probe concentrating in lysosomes. HER2-hIC7L intravenously administered to mice clearly and specifically visualized HER2-positive tumors by in vivo optical imaging. These results indicate that HER2-hIC7L is a potential activatable NIR probe for sensitive tumor diagnosis. Near-infrared probes that activate their fluorescence following interaction with specific biomolecules are desirable for noninvasive and sensitive tumor detection due to minimal tissue interference. This team of authors developed a probe termed hIC7L and demonstrate its potential in HER2 tumor diagnosis. © 2014.

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Author and article information

Journal

Journal ID (nlm-ta): RSC Adv

Journal ID (iso-abbrev): RSC Adv

Journal ID (publisher-id): RA

Journal ID (coden): RSCACL

Title: RSC Advances

Publisher: The Royal Society of Chemistry

ISSN (Electronic): 2046-2069

Publication date (Electronic, pub): 17 July 2020

Publication date (Electronic, collection): 15 July 2020

Publication date PMC-release: 17 July 2020

Volume: 10

Issue: 45

Pages: 26777-26791

Affiliations

[a] Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University Henan 450018 China

[b] Department of Instrumentation & Electronics Engineering, Jadavpur University Kolkata 700106 India

[c] School of Sciences, P P Savani University NH-8, GETCO, Near Biltech, Village: Dhamdod, Kosamba, Dist. Surat 394125 Gujarat India

[d] Department of Chemical Engineering, King Saud University P.O. Box 800 Riyadh 11421 Saudi Arabia

[e] Department for Management of Science and Technology Development, Ton Duc Thang University Ho Chi Minh City Vietnam

[f] Faculty of Applied Sciences, Ton Duc Thang University Ho Chi Minh City Vietnam rohit.vekariya@ 123456tdtu.edu.vn

Author information

Nadavala Siva Kumar https://orcid.org/0000-0003-3210-8254

Rohit L. Vekariya https://orcid.org/0000-0001-6195-114X

Article

Publisher ID: d0ra03491f

DOI: 10.1039/d0ra03491f

PMC ID: 9055574

PubMed ID: 35515778

SO-VID: c842dbbd-92f0-4aa6-a506-e0fa4c9bfa6f

History

Date received : 21 April 2020

Date accepted : 3 July 2020

Page count

Pages: 15

Funding

Funded by: National Natural Science Foundation of China, doi 10.13039/501100001809;

Award ID: 81903623

Funded by: China Postdoctoral Science Foundation, doi 10.13039/501100002858;

Award ID: 2019M652586

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A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems

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RNA drug delivery

Most cited references 11

Drug Delivery Nanoparticles in Skin Cancers

Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases.

Micelle-based activatable probe for in vivo near-infrared optical imaging of cancer biomolecules.

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Cited by 109

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