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      Application of P-31 Nuclear Magnetic Resonance Spectroscopy to a New Experimental Kidney Perfusion Model Using Cadaveric Porcine Kidneys from Slaughterhouse

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          Larger NMR magnets with relatively high field strengths have become available recently, allowing the application of magnetic resonance spectroscopy (MRS) in larger mammalian organs. The aim of this study was to develop and test a new and simple kidney perfusion model from slaughterhouse swine using a new 4.7-tesla/40-cm diameter system, with the intention behind to provide a human-like mammalian experimental kidney perfusion model, and to avoid sensitive in vivo animal experiments on higher-developed mammalians. 35 pig kidneys obtained 10–15 min post mortem were studied to evaluate and define conditions for optimum metabolic preservation with the following perfusion protocols: (1) immediate plegia with cold Collins solution, 1–3 h cold storage, P-31 MRS; (2) immediate plegia, 1–3 h cold storage, blood reperfusion, P-31 MRS; (3) immediate blood reperfusion, plegia, 1–3 h cold storage, blood reperfusion, P-31 MRS; (4) immediate blood reperfusion, plegia, 24 h cold storage, blood reperfusion, P-31 MRS. P-31 MRS at 81 MHz with a double-tuned surface coil yielded the following results: Protocol, No.

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          Author and article information

          S. Karger AG
          11 December 2008
          : 57
          : 3
          : 340-348
          Divisions of Nuclear Medicine and Nuclear Magnetic Resonance Spectroscopy, University of Ulm, FRG
          186285 Nephron 1991;57:340–348
          © 1991 S. Karger AG, Basel

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          Pages: 9
          Original Paper


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