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      Protein C, Protein S, and Antithrombin III Levels in Patients on Continuous Ambulatory Peritoneal Dialysis and Hemodialysis

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          Abstract

          Patients undergoing dialysis are subject to risk of thrombotic complications. We studied the plasma levels of natural coagulation inhibitors including protein C (PC), protein S (PS), and antithrombin III (AT III) in 20 patients on hemodialysis and 20 patients on continuous ambulatory peritoneal dialysis (CAPD). Total PS antigen, free PS antigen, immunological and functional activities of PC and AT III were measured. Hemodialysis patients had a higher total PS level but a lower free PS level compared with healthy controls. Both the immunological and functional activities of AT III in hemodialysis patients were significantly lower than those of controls. With the exception of total PS level, CAPD patients had comparable or even higher plasma level of natural coagulation inhibitors compared with healthy controls. Furthermore, the plasma levels of PC, PS, and AT III were significantly lower in hemodialysis patients compared with CAPD patients despite greater daily losses of PC, PS, and AT III through urinary and peritoneal routes in patients on CAPD treatment. Most of the AT III in the peritoneal dialysate was still functionally active but most of the PC was inactive. Our observations suggest an effective turnover and production of these natural coagulation inhibitors in patients on CAPD therapy but a similar compensatory mechanism does not operate efficiently in patients receiving hemodialysis.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1990
          1990
          10 December 2008
          : 56
          : 3
          : 271-276
          Affiliations
          Departments of aMedicine and bPediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
          Article
          186153 Nephron 1990;56:271–276
          10.1159/000186153
          2150218
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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