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      Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.

      Nature genetics
      Apolipoprotein A-II, genetics, Case-Control Studies, Coronary Artery Disease, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Haplotypes, Humans, Lipoprotein(a), Multigene Family, Organic Cation Transport Proteins, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk Factors

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          Abstract

          We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

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