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      Short-term surgical missions to resource-limited settings in the wake of the COVID-19 pandemic

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          Abstract

          Dear Editor, The significant impact of the SARS-CoV-2 (COVID-19) pandemic has been reported in almost every country around the world. 1 , 2 After months of imposed lockdown, many countries are now beginning to cautiously ease their restrictions. In the absence of a vaccine, we face a ‘new normal’ living alongside COVID-19 for an unknown period of time, with the real possibility of a second wave in the months to come. As the dust settles on what has been an incredible international collaborative effort in the acute phase response to COVID-19, we are just starting to look beyond our own borders at the impending humanitarian crisis that will undoubtably face many low- and middle-income countries in the wake of the pandemic. The knock-on effects of the worst financial down-turn in decades coupled with restricted access to humanitarian aid will undoubtably lead to increased poverty, malnutrition and resurgences in preventable diseases. For many Surgeons, annual short-term surgical missions to resource-limited settings give an opportunity to teach and learn from local surgeons and help address some of the major surgical inequalities detailed in the Lancet 2030 commission. 3 Events in recent months will make almost all surgical mission trips dealing with elective cases unlikely for the foreseeable future. Short-term barriers to running future missions include travel restrictions, enforced quarantine of up to 14 days on arrival in new countries, significant risks to patients and volunteers, challenges in obtaining valid indemnity cover, reallocation of equipment and PPE, and a lack of ITU beds. Diverting staff, equipment and hospital beds away from patients and local health care workers in urgent need is clearly unethical at the present time. Now, more than ever, collaboration and innovation, and adapting to a new way of helping those most in need is required. Our experience of short-term surgical missions has been treating children and adults with complex facial disfigurement in Ethiopia, through the charity Project Harar. The Ethiopian government, which has been proactive in its response to coronavirus, has called upon all NGOs to back their response and have been requesting excess supplies and PPE. 4 Many NGOs and their volunteers, from all backgrounds, are now fundraising for water barrels, soap and PPE in a concerted effort to help. Many medical charities will, for the first time, find themselves unable to perform face-to-face patient follow-up in the months or years that follow. Over the past two years we have successfully implemented a remote follow-up programme, employing low cost smart phone technology to take photographs and ask simple triage questions to patients in their rural villages. During our 2018 pilot we were able to follow-up 79 % of patients selected, and identified six patients that had complications requiring further management. Importantly the remaining patients were discharged and did not require to travel back to Addis Ababa for unnecessary follow-up. We hope this technique will be useful in the current climate for many surgical NGOs facing access restrictions and follow-up limitations. Finally, one of the major elements of any surgical mission is education and training. We are pleased to see many of our colleagues from around the world, including Addis Ababa, during the new era of excellent international educational webinars. 5 It is our intention, even if we cannot run our 2021 surgical mission to Addis Ababa, that we will still run our third annual head and neck conference remotely, using now tried and tested virtual platforms. The future of medical missions is currently in doubt. However, fundraising efforts to support colleagues in resource-limited settings and a longer-term commitment to careful patient follow-up, development of remote education opportunities, and ensuring relationships are developed not lost, will build a sustainable platform for future missions after COVID-19 is over. Declaration of Competing Interest None

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          Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

          Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p<0·0001), and d-dimer greater than 1 μg/mL (18·42, 2·64–128·55; p=0·0033) on admission. Median duration of viral shedding was 20·0 days (IQR 17·0–24·0) in survivors, but SARS-CoV-2 was detectable until death in non-survivors. The longest observed duration of viral shedding in survivors was 37 days. Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.
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            COVID-19 in Brazil: “So what?”

            The Lancet (2020)
            The coronavirus disease 2019 (COVID-19) pandemic reached Latin America later than other continents. The first case recorded in Brazil was on Feb 25, 2020. But now, Brazil has the most cases and deaths in Latin America (105 222 cases and 7288 deaths as of May 4), and these are probably substantial underestimates. Even more worryingly, the doubling of the rate of deaths is estimated at only 5 days and a recent study by Imperial College (London, UK), which analysed the active transmission rate of COVID-19 in 48 countries, showed that Brazil is the country with the highest rate of transmission (R0 of 2·81). Large cities such as São Paulo and Rio de Janeiro are the main hotspots now but there are concerns and early signs that infections are moving inland into smaller cities with inadequate provisions of intensive care beds and ventilators. Yet, perhaps the biggest threat to Brazil's COVID-19 response is its president, Jair Bolsonaro. When asked by journalists last week about the rapidly increasing numbers of COVID-19 cases, he responded: “So what? What do you want me to do?” He not only continues to sow confusion by openly flouting and discouraging the sensible measures of physical distancing and lockdown brought in by state governors and city mayors but has also lost two important and influential ministers in the past 3 weeks. First, on April 16, Luiz Henrique Mandetta, the respected and well liked Health Minister, was sacked after a television interview, in which he strongly criticised Bolsonaro's actions and called for unity, or else risk leaving the 210 million Brazilians utterly confused. Then on April 24, following the removal of the head of Brazil's federal police by Bolsonaro, Justice Minister Sérgio Moro, one of the most powerful figures of the right-wing government and appointed by Bolsonaro to combat corruption, announced his resignation. Such disarray at the heart of the administration is a deadly distraction in the middle of a public health emergency and is also a stark sign that Brazil's leadership has lost its moral compass, if it ever had one. Even without the vacuum of political actions at federal level, Brazil would have a difficult time to combat COVID-19. About 13 million Brazilians live in favelas, often with more than three people per room and little access to clean water. Physical distancing and hygiene recommendations are near impossible to follow in these environments—many favelas have organised themselves to implement measures as best as possible. Brazil has a large informal employment sector with many sources of income no longer an option. The Indigenous population has been under severe threat even before the COVID-19 outbreak because the government has been ignoring or even encouraging illegal mining and logging in the Amazon rainforest. These loggers and miners now risk bringing COVID-19 to remote populations. An open letter on May 3 by a global coalition of artists, celebrities, scientists, and intellectuals, organised by the Brazilian photojournalist Sebastião Salgado, warns of an impending genocide. What are the health and science community and civil society doing in a country known for its activism and outspoken opposition to injustice and inequity and with health as a constitutional right? Many scientific organisations, such as the Brazilian Academy of Sciences and ABRASCO, have long-opposed Bolsonaro because of severe cuts in the science budget and a more general demolition of social security and public services. In the context of COVID-19, many organisations have launched manifestos aimed at the public—such as Pact for Life and Brazil—and written statements and pleas to government officials calling for unity and joined up solutions. Pot-banging from balconies as protest during presidential announcements happens frequently. There is much research going on, from basic science to epidemiology, and there is rapid production of personal protective equipment, respirators, and testing kits. These are hopeful actions. Yet, leadership at the highest level of government is crucial in quickly averting the worst outcome of this pandemic, as is evident from other countries. In our 2009 Brazil Series, the authors concluded: “The challenge is ultimately political, requiring continuous engagement by Brazilian society as a whole to secure the right to health for all Brazilian people.” Brazil as a country must come together to give a clear answer to the “So what?” by its President. He needs to drastically change course or must be the next to go. © 2020 Bruna Prado/Getty Images 2020 Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
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              COVID-19 Lockdown Learning: The uprising of Virtual Teaching

              The global health pandemic with COVID-19 has hugely impacted the international health community causing significant disruption to routine clinical practices as well as teaching and training. The speed and scale of viral spread have overwhelmed health services across the globe and has required diversion of all clinical resources to save lives and protect health care workers. Redeployment of trainees into medical specialities has virtually halted their training within chosen subspecialties. Within a few weeks, COVID-19 has forced the surgical community to rapidly adapt to a completely new way of delivering care. Guidelines for the treatment of acute conditions and oncology patients are being re-evaluated. Moreover, each procedure that takes place is being evaluated with regards to potential for both patients and practitioners. COVID-19 has truly changed the way that surgeons of all specialties think, practice and operate. In these unprecedented times, it is a challenge to facilitate standard teaching and training modules. As it became imperative to maintain social distancing in order to achieve victory over this pandemic, the use of webinars has gained massive popularity within multiple healthcare domains. The General Medical Council (GMC) in setting out the principles for good medical practice, recognises the importance of continuous professional development in order to maintain and develop performance and skills[1]. Within this pandemic, it has become imperative that trainees and healthcare professionals are kept engaged within their specialities. From basic telehealth platforms to more complex augmented reality solutions, technology is increasingly being deployed to foster connectivity between surgical teams in order to disseminate best practice and share expertise on a global scale. Webinars and virtual collaboration platforms, allow the advantage of face to face learning with an interactive exchange in real-time. In addition to this, sufficient learning tools can be provided for a large number of learners, multiple chat functions like live quiz and polls offer helpful learning modalities. Current literature demonstrates that webinars are a reliable tool to deliver a near-normal interaction between the audience and the lecturer[2,3]. Under normal circumstances, virtual learning is often underutilised since humans are sociable and enjoy a person to person interaction more. However, these virtual environments allow for synchronous sessions which enable the trainer and trainee to share ideas and questions in real-time, located anywhere in the world. The wide variety of webinars available online have provided a new level of convenience in medical education, where learners can engage in gaining education on a platform where online availability can be incorporated easily even within the time constraints of regular working days. Over the past five weeks, we have observed an influx of online teaching modules. The benefits of these sessions are clear; they provide a platform wherein the comfort of the trainee's home; they have access to world-class surgeons providing teaching in real-time. This traditionally was only available if one were to attend a meeting, which in itself is associated with an expense. We have converted our regular inhouse teaching by utilising video communication through platforms, Zoom, and virtual collaboration and augmented reality platforms, Proximie. The teaching schedule is designed to complement the curriculum for plastic surgery training and address the hot topics caused by the Covid-19 pandemic. Initial feedback from trainees has been extremely positive and judging through the attendance rates at webinars throughout the country we believe this trend of online learning is here to stay. In our experience, online teaching has provided an easily accessible resource of teaching that is available to use when convenient. This is especially true for many surgeons that adapted to a new work schedule and were redeployed to help in other clinical areas such as intensive care setting resulted in an unpredictable timetable. Furthermore, this form of teaching has provided a break in the physical barriers to training and encouraged interaction in a way that seems more favourable to participants. [4] Feedback surveys show a high satisfaction rate from participants. Also, trainees were able to comment on improvement in morale as redeployment to other specialities caused certain anxiety regarding training. Keeping trainees engaged with the speciality is also vital in this time of uncertainty. Historically, the most common challenges faced during the utilisation of electronic platforms to deliver virtual learning were the technical challenges. [5] However, owing to advances in technology and internet connection. High-quality video and sound have been maintained throughout the sessions. Security concerns were raised with platforms like Zoom even with password protection. Though some of the concerns have been addressed it is important to bear this in mind and not share confidential information on these platforms and ensure that your software is frequently updated. In summary, virtual learning utilising webinars has enabled continuous professional development in our unit and others across the world. In our experience, webinars are highly efficient, flexible and allow surgeons in training to access learning material from a wide geographic area ensuring at the same time, compliance with the social distancing guidance. Online teaching has globalised teaching in pure form and in the future, may replace face-to-face lectures. Fig. 1, Fig. 2 Fig. 1 Use of video communication for live dial in to the operating room, free tissue transfer surgery in this case Fig 1 Fig. 2 Cadaveric Masterclass demonstrating use of virtual platforms in practical learning, display of practical tracheostomy teaching Fig 2 References: 1. Good Medical Practice (2013). [online] Available at: [Accessed 28/04/2020]. 2. Wang, S. K., & Hsu, H. Y., “Use of the webinar tool (Elluminate) to support training: The effects of webinar-learning implementation from student-trainers’ perspective,” Journal of Interactive Online learning, 7(3), 175-194, 2008. 3. Cornelius, S., 2013. Facilitating in a demanding environment: Experiences of teaching in virtual classrooms using web conferencing. British Journal of Educational Technology, 45(2), pp.260-271. 4. Gegenfurtner, A., Schwab, N. and Ebner, C. (2018), ‘“There's no need to drive from A to B”: exploring the lived experience of students and lecturers with digital learning in higher education’, Bavarian Journal of Applied Sciences, 4, 310–22. https://doi.org/10.25929/bjas.v4i1.50. 5. C Johnson, K Corazzini, R Shaw. Assessing the feasibility of using virtual environments in distance education Knowledge Management & E-Learning: An International Journal, 2011.. pp.5-16.
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                Author and article information

                Contributors
                Journal
                J Plast Reconstr Aesthet Surg
                J Plast Reconstr Aesthet Surg
                Journal of Plastic, Reconstructive & Aesthetic Surgery
                Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.
                1748-6815
                1878-0539
                29 August 2020
                29 August 2020
                Affiliations
                [a ]Plastic Surgery Registrar, Canniesburn Plastic Surgery and Burns Unit, Glasgow Royal Infirmary, Scotland, United Kingdom
                [b ]Consultant Oral Surgeon, Oral Surgery Department, Guys Dental Institute, Guys & St Thomas NHS Foundation Trust, London, United Kingdom
                [c ]Consultant Cranio-Maxillofacial and Reconstructive Surgeon, Saint Judes General Hospital, Federal Hospital of Rio de Janeiro, Rio de Janeiro, Brazil
                [d ]Senior House Officer, Dental Student, King's College London, Faculty of Dentistry, Oral and Craniofacial Sciences, Guy's Tower, Guy's Hospital, London, United Kingdom
                [e ]Professor of Plastic and Reconstructive Surgery, Department of Plastic and Reconstructive Surgery, University of Bordeaux, France
                [f ]Professor of Oral and Maxillofacial Surgery, Department of Head and Neck Surgery, University College London Hospital, London, United Kingdom
                Author notes
                [* ]Corresponding author: Mr Calum S. Honeyman, Canniesburn Plastic Surgery and Burns Unit, Glasgow Royal Infirmary, 84 Castle Street, G4 OSE, Scotland, United Kingdom, +447702155312 c.s.honeyman@ 123456gmail.com
                Article
                S1748-6815(20)30379-X
                10.1016/j.bjps.2020.08.048
                7455554
                c8621c6c-5c22-4632-b632-8abc985214d6
                © 2020 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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                : 9 June 2020
                : 17 August 2020
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