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      Apolipoprotein(a) Phenotype, Albumin Clearance, and Plasma Levels of Lipoprotein(a) in Peritoneal Dialysis

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          This cross-sectional study was undertaken to examine the relationship between plasma lipoprotein(a) [Lp(a)] level and peritoneal dialysis (PD) albumin clearance while controlling for the influence of the apolipoprotein(a) [apo(a)] phenotype. Plasma Lp(a) level, PD albumin clearance, and apo(a) phenotype (high vs. low molecular weight, HMW vs. LMW) were determined in 54 PD patients. Apo(a) phenotypes were 24 LMW and 30 HMW. The plasma Lp(a) level was high (>65 nmol/l) in 17 of 24 patients with LMW phenotype versus 2 of 30 with HMW phenotype (χ<sup>2</sup>, p < 0.01). Spearman correlation coefficients of Lp(a) with PD, urine, and total albumin clearances were –0.05 (p = 0.74), –0.04 (p = 0.80), and –0.09 (p = 0.51), respectively. The apo(a) isoform size was the only significant predictor of Lp(a) in multivariate analysis. In this study, there was no association between PD albumin clearance and Lp(a) level. The association between apo(a) phenotype and Lp(a) level is in keeping with studies in the general population. There is a strong genetic influence on Lp(a) level in PD patients.

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          Identification of 34 apolipoprotein(a) isoforms: differential expression of apolipoprotein(a) alleles between American blacks and whites.

          A total of 34 different apo(a) isoforms was identified in a population sample of 806 American Whites and 701 American Blacks by a high resolution SDS-agarose gel electrophoretic method followed by immunoblotting. Among the 1507 individuals tested, 79% revealed double-banded phenotypes and 21% single-banded phenotypes. The frequencies of the apo(a) isoforms differed between American Blacks and Whites (p < 0.001).
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            Preventing coronary artery disease in the West of Scotland: implications for primary prevention


              Author and article information

              S. Karger AG
              25 May 2001
              : 88
              : 2
              : 168-169
              aQueen’s University, Kingston, Ont., Canada; bUniversity of Washington, Seattle, Wash., USA
              45979 Nephron 2001;88:168–169
              © 2001 S. Karger AG, Basel

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              References: 9, Pages: 2
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