Objective Based on observational, longitudinal and intervention study of common diseases among students in Jiangsu Province, this paper presents the current progress of two-year follow up of myopia cohort regarding the association between growth parameters with progression of myopia among children and adolescents in areas with rapid economic growth.
Methods This survey adopted the stratified cluster sampling method for school selection. The full-automatic computer optometry (TOPCON RM800) was used to track myopia-related parameters for all participants from 2019 to 2020 under the condition of mydriasis (compound topicamide eye drops). Relationship between growth parameters of children and adolescents and the incidence and progression of myopia was analyzed by using Cox regression multiple statistical model.
Results The myopia rates of students from grade 1 to grade 3 in 2019 were 5.4%, 21.5% and 37.3% respectively. After one year, the myopia rates of all school stages increased to 25.3%, 43.3% and 58.1% respectively (χ 2 = 53.59, 49.63, 32.52, P<0.01). The mean diopter of right eye and left eye after mydriasis were (0.30±1.24/0.39±1.26) D in 2019 and (−0.33±1.54/−0.19±1.55) D in 2020, respectively based on Cox multiple regression results, age ( HR = 1.21, 95% CI = 1.09–1.34), naked eye vision ( HR = 0.08, 95% CI = 0.07–0.11), height ( HR = 0.98, 95% CI = 0.97–0.99) showed a strong correlation with the incidence and progression of myopia ( P<0.05).
Conclusion Myopia is growing rapidly in the central region of Jiangsu Province. It is suggested that diopter, axial length, naked eye vision, age, height and other indicators should be included in the refractive archives of children and adolescents in the region.
【摘要】 目的 基于江苏省学生常见病监测、队列及干预研究探索生长参数与近视发生发展的关系, 为城市化进程较快 地区儿童屈光档案的建立提供理论依据。 方法 采用以学校为单位的分层整群抽样方法, 共选取江苏省仪征市学生1 187 名, 并对2019—2020年追踪人群近视及其相关参数进行差异性比较, 采用Cox回归多元统计模型探索儿童青少年生长参 数与近视发生发展的关系。 结果 2019 年一年级至三年级学生近视率分别为 5.4%, 21.5%, 37.3%, 2020 年各学段近视率 分别增长至25.3%, 43.3%, 58.1% (χ 2 值分别为 53.59, 49.63, 32.52, P 值均<0.01)。2019 年右眼/左眼散瞳后屈光度均值分 别为 (0.30±1.24/0.39±1.26) D, 2020 年右眼/左眼散瞳后屈光度均值分别为 (−0.33±1.54/−0.19±1.55) D。基于Cox多元回 归结果显示, 年龄 ( HR = 1.21, 95% CI = 1.09~1.34)、裸眼视力 ( HR = 0.08, 95% CI = 0.07~0.11)、身髙 ( HR =0.98, 95% CI = 0.97~0.99) 与近视发生发展呈现相关性 ( P 值均<0.05)。 结论 江苏省中部地区近视增长速度快, 建议屈光度、眼轴长度、裸眼视力、年龄、身髙等指标纳人地区儿童青少年屈光档案。