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      Concurrent Measurement of Left Ventricular dP/dt max, Isometric Contractile Force and Cardiac Loading in the Intact Monkey

      Cardiology

      S. Karger AG

      Left ventricular dP/dtmaχ , Isometric contractile force, Preload, Afterload, Contractility, Intact monkey

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          Abstract

          Eight rhesus monkeys were implanted with catheters to measure left ventricular and arterial pressure; an isometric strain gauge was sutured onto the myocardium in four of them. The maximum rate of rise of ventricular pressure (dP/dt<sub>maχ</sub>) and left ventricular force of contraction (LVF) were determined during positive inotropic responses elicited by administration of isoproterenol and by several controlled behavioral situations. Both dP/dt and LVF increased concomitantly during the testing situations; linear correlation coefficients relating the variables typically exceeded 0.8 (p < 0.01). The possible influence of altered loading conditions on dP/dt was investigated in four animals after surgical denervation of their hearts to eliminate direct neural reflex effects. Arterial pressure and left ventricular filling pressure were increased by infusion of phenylephrine and decreased by nitroglycerine. Alterations in loading did not exert any significant influence on dP/dt<sub>maχ</sub> in the intact monkey with a denervated heart.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1974
          1974
          29 October 2008
          : 59
          : 5
          : 304-318
          Affiliations
          Division of Behavioral Biology, The Johns Hopkins University School of Medicine, Baltimore, Md.
          Article
          169680 Cardiology 1974;59:304–318
          10.1159/000169680
          4218800
          © 1974 S. Karger AG, Basel

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          Page count
          Pages: 15
          Categories
          Paper

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