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      • Record: found
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      New Scalarane Sesterterpenoids from the Formosan Sponge Ircinia felix

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          Abstract

          Five new scalarane sesterterpenoids, felixins A–E ( 1– 5), were isolated from the Formosan sponge Ircinia felix. The structures of scalaranes 1– 5 were elucidated on the basis of spectroscopic analysis. Cytotoxicity of scalaranes 1– 5 against the proliferation of a limited panel of tumor cell lines was evaluated.

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          Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

          M Alley, D Scudiero, A. Monks … (1988)
          For the past 30 years strategies for the preclinical discovery and development of potential anticancer agents have been based largely upon the testing of agents in mice bearing transplantable leukemias and solid tumors derived from a limited number of murine as well as human sources. The feasibility of implementing an alternate approach, namely combined in vitro/in vivo screening for selective cytotoxicity among panels of human tumor cell lines derived from a broad spectrum of human solid tumors is under investigation. A group of 30 cell lines acquired from a variety of sources and representing 8 lung cancer pathologies as well as 76 cell lines representing 10 other categories of human cancer (carcinomas of colon, breast, kidney, prostate, ovary, head and neck; glioma; leukemia; melanoma; and sarcoma) have exhibited acceptable growth characteristics and suitable colorimetric profiles in a single, standard culture medium. Measurements of in vitro growth in microculture wells by cell-mediated reduction of tetrazolium showed excellent correlation (0.89 less than r2 less than 0.98) with measurements of cellular protein in adherent cell line cultures as well as viable cell count in suspension cell line cultures (0.94 less than r2 less than 0.99). Since the microculture tetrazolium assay provides sensitive and reproducible indices of growth as well as drug sensitivity in individual cell lines over the course of multiple passages and several months' cultivation, it appears suitable for initial-stage in vitro drug screening.
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            Biological Activities of Aqueous and Organic Extracts from Tropical Marine Sponges

            Kristina Sepčić, Silke Kauferstein, Dietrich Mebs … (2010)
            We report on screening tests of 66 extracts obtained from 35 marine sponge species from the Caribbean Sea (Curaçao) and from eight species from the Great Barrier Reef (Lizard Island). Extracts were prepared in aqueous and organic solvents and were tested for hemolytic, hemagglutinating, antibacterial and anti-acetylcholinesterase (AChE) activities, as well as their ability to inhibit or activate cell protein phosphatase 1 (PP1). The most interesting activities were obtained from extracts of Ircinia felix, Pandaros acanthifolium, Topsentia ophiraphidites, Verongula rigida and Neofibularia nolitangere. Aqueous and organic extracts of I. felix and V. rigida showed strong antibacterial activity. Topsentia aqueous and some organic extracts were strongly hemolytic, as were all organic extracts from I. felix. The strongest hemolytic activity was observed in aqueous extracts from P. acanthifolium. Organic extracts of N. nolitangere and I. felix inhibited PP1. The aqueous extract from Myrmekioderma styx possessed the strongest hemagglutinating activity, whilst AChE inhibiting activity was found only in a few sponges and was generally weak, except in the methanolic extract of T. ophiraphidites.
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              Defenses of Caribbean sponges against invertebrate predators. II. Assays with sea stars

              B. Waddell, JR Pawlik (2000)
              Article 0 comments Cited 13 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Anake Kijjoa: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Mar Drugs
                Journal ID (iso-abbrev): Mar Drugs
                Journal ID (publisher-id): marinedrugs
                Title: Marine Drugs
                Publisher: MDPI
                ISSN (Electronic): 1660-3397
                Publication date (Electronic): 14 July 2015
                Publication date Collection: July 2015
                Volume: 13
                Issue: 7
                Pages: 4296-4309
                Affiliations
                [1 ]Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mails: spire0123456@ 123456yahoo.com.tw (Y.-Y.L.); jinx6609@ 123456nmmba.gov.tw (M.-C.L.); wanglh@ 123456nmmba.gov.tw (L.-H.W.)
                [2 ]National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
                [3 ]Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan; E-Mail: jjchen@ 123456tajen.edu.tw
                [4 ]Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan; E-Mail: lsfang@ 123456csu.edu.tw
                [5 ]School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
                [6 ]Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
                [7 ]Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
                [8 ]Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
                [9 ]Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
                Author notes
                [* ]Authors to whom correspondence should be addressed; E-Mails: yachwu@ 123456mail.cmu.edu.tw (Y.-C.W.); pjsung@ 123456nmmba.gov.tw (P.-J.S.); Tel.: +886-4-220-57513 (Y.-C.W.); +886-8-882-5037 (P.-J.S.); Fax: +886-4-220-60248 (Y.-C.W.); +886-8-882-5087 (P.-J.S.).
                Article
                Publisher ID: marinedrugs-13-04296
                DOI: 10.3390/md13074296
                PMC ID: 4515618
                PubMed ID: 26184237
                SO-VID: c8ef34ba-f0ad-42ef-883f-76f0b426b0b5
                Copyright © © 2015 by the authors; licensee MDPI, Basel, Switzerland.
                License:

                This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 04 June 2015
                Date accepted : 08 July 2015
                Categories
                Subject: Article

                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: ircinia felix,sponge,scalarane,sesterterpenoid,cytotoxicity
                Data availability:
                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: ircinia felix, sponge, scalarane, sesterterpenoid, cytotoxicity

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