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      The NLRP3 inflammasome: a sensor for metabolic danger?

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          Abstract

          Interleukin-1beta (IL-1beta), reactive oxygen species (ROS), and thioredoxin-interacting protein (TXNIP) are all implicated in the pathogenesis of type 2 diabetes mellitus (T2DM). Here we review mechanisms directing IL-1beta production and its pathogenic role in islet dysfunction during chronic hyperglycemia. In doing so, we integrate previously disparate disease-driving mechanisms for IL-1beta, ROS, and TXNIP in T2DM into one unifying model in which the NLRP3 inflammasome plays a central role. The NLRP3 inflammasome also drives IL-1beta maturation and secretion in another disease of metabolic dysregulation, gout. Thus, we propose that the NLRP3 inflammasome contributes to the pathogenesis of T2DM and gout by functioning as a sensor for metabolic stress.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          1095-9203
          0036-8075
          Jan 15 2010
          : 327
          : 5963
          Affiliations
          [1 ] Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.
          Article
          327/5963/296
          10.1126/science.1184003
          20075245
          c90828bc-473b-4c18-9b7d-3db780d83229
          History

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