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      Is the Bioreactivity of Vitamin-E-Modified Dialyzer an Expression of Increased Plasmatic Vitamin E Concentration?

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      S. Karger AG

      Hemodialysis, Vitamin E-coated dialyzer, Acrylonitrile, Polysulphone

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          The present study was designed to test the biocompatibility of a new vitamin E-modified multilayer membrane compared with highly biocompatible polysulphone dialyzer and acrylonitrile dialyzer. Thirty patients (mean age 53.2 ± 15.3 SD years; dialytic age 36 ± 5.6 months) were selected for the study. The study was divided into three periods of 6 months (phases A, B and C). In the first phase (from Jan. 1999 to June 1999) patients undergoing maintenance bicarbonate dialysis were randomly divided into three filter groups composed, respectively, of 10 patients: acrylonitrile group, polysulphone group and vitamin E-coated dialyzer group. In the phase B (from July 1999 to Dec. 1999) and in the phase C (from Jan. 2000 to June 2000), all three groups changed their own dialysis membranes. Vitamin E-coated dialyzer causes significant decreases in β<sub>2</sub>-microglobulin, ferritin and immunoglobulin G, a normalization of complement C3 and an increase of plasmatic vitamin E compared to other filters. In the VE group homocysteine decreases but not in a significant manner. In addition, this dialyzer seems not to influence lipid pattern and protein-energy malnutrition parameters. These results clearly show a positive effect of this new filter in influencing different biochemical parameters, perhaps saving vitamin E and reducing polymorphonuclear cell activation.

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          Author and article information

          S. Karger AG
          October 2002
          02 September 2002
          : 92
          : 2
          : 487-489
          Nephrology and Dialysis Operative Unit, S. Giovanni in Fiore Hospital, Crotone, Italy
          63282 Nephron 2002;92:487–489
          © 2002 S. Karger AG, Basel

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