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      Thrombin signalling and protease-activated receptors.

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      Nature
      Springer Science and Business Media LLC

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          Abstract

          How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          0028-0836
          0028-0836
          Sep 14 2000
          : 407
          : 6801
          Affiliations
          [1 ] Cardiovascular Research Institute and Department of Medicine, University of California at San Francisco, 94143-0130, USA. coughlin@cvrimail.ucsf.edu
          Article
          10.1038/35025229
          11001069
          c92068db-cc0a-46f8-a44b-7f3ef7664515

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