We report multifocal choroiditis associated with progressive subretinal fibrosis in 2 healthy, young, myopic women. One of the patients showed bilateral choroiditis but unilateral subretinal fibrosis. The other had myopic anisometropia, and choroidal lesions developed only in the more myopic eye. Systemic evaluation was noncontributory. We suggest that local factors, and unknown hormonal irregularities in young women, may play a role in the development of this rare disorder.