7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes for oral cancer in the hamster cheek pouch model.

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The application of boron neutron capture therapy (BNCT) mediated by liposomes containing (10)B-enriched polyhedral borane and carborane derivatives for the treatment of head and neck cancer in the hamster cheek pouch oral cancer model is presented. These liposomes are composed of an equimolar ratio of cholesterol and 1,2-distearoyl-sn-glycero-3-phosphocholine, incorporating K[nido-7-CH3(CH2)15-7,8-C2B9H11] (MAC) in the bilayer membrane while encapsulating the hydrophilic species Na3[ae-B20H17NH3] (TAC) in the aqueous core. Unilamellar liposomes with a mean diameter of 83 nm were administered i.v. in hamsters. After 48 h, the boron concentration in tumors was 67 ± 16 ppm whereas the precancerous tissue contained 11 ± 6 ppm, and the tumor/normal pouch tissue boron concentration ratio was 10:1. Neutron irradiation giving a 5-Gy dose to precancerous tissue (corresponding to 21 Gy in tumor) resulted in an overall tumor response (OR) of 70% after a 4-wk posttreatment period. In contrast, the beam-only protocol gave an OR rate of only 28%. Once-repeated BNCT treatment with readministration of liposomes at an interval of 4, 6, or 8 wk resulted in OR rates of 70-88%, of which the complete response ranged from 37% to 52%. Because of the good therapeutic outcome, it was possible to extend the follow-up of BNCT treatment groups to 16 wk after the first treatment. No radiotoxicity to normal tissue was observed. A salient advantage of these liposomes was that only mild mucositis was observed in dose-limiting precancerous tissue with a sustained tumor response of 70-88%.

          Related collections

          Author and article information

          Journal
          Proc. Natl. Acad. Sci. U.S.A.
          Proceedings of the National Academy of Sciences of the United States of America
          Proceedings of the National Academy of Sciences
          1091-6490
          0027-8424
          Nov 11 2014
          : 111
          : 45
          Affiliations
          [1 ] Comisión Nacional de Energía Atómica, B1650KNA San Martin, Buenos Aires, Argentina;
          [2 ] International Institute of Nano and Molecular Medicine, University of Missouri, Columbia, MO 65211; hawthornem@missouri.edu schwint@cnea.gov.ar.
          [3 ] International Institute of Nano and Molecular Medicine, University of Missouri, Columbia, MO 65211;
          [4 ] Idaho National Laboratory, Idaho Falls, ID 83415; and.
          [5 ] Comisión Nacional de Energía Atómica, B1650KNA San Martin, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, 1033 Ciudad Autónoma de Buenos Aires, Argentina.
          [6 ] Comisión Nacional de Energía Atómica, B1650KNA San Martin, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, 1033 Ciudad Autónoma de Buenos Aires, Argentina hawthornem@missouri.edu schwint@cnea.gov.ar.
          Article
          1410865111
          10.1073/pnas.1410865111
          4234606
          25349432
          c9362142-b3b0-471f-83aa-9889d22ecaea
          History

          BNCT,boronated liposomes,cancer,neutron radiation,oncology
          BNCT, boronated liposomes, cancer, neutron radiation, oncology

          Comments

          Comment on this article