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      Cortical inhibitory neurons and schizophrenia.

      Nature reviews. Neuroscience

      Animals, Cerebral Cortex, cytology, physiology, physiopathology, Humans, Nerve Net, pathology, Neural Inhibition, Neurons, Schizophrenia

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          Abstract

          Impairments in certain cognitive functions, such as working memory, are core features of schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA (gamma-aminobutyric acid) synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia. Despite both pre- and postsynaptic compensatory responses, the resulting alteration in perisomatic inhibition of pyramidal neurons contributes to a diminished capacity for the gamma-frequency synchronized neuronal activity that is required for working memory function. These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia.

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          Journal
          15803162
          10.1038/nrn1648

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