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      Role of Renal Nerves in Volume Expansion in Chronic Hypoxic Rats

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          Abstract

          This work was designed to study the significance of the renal nerves in chronic hypoxic (high-altitude; HA) rats after saline loading. Female Wistar rats (200-290 g) under sodium pentobarbital (40 mg/kg i.p.) anesthesia were used in these experiments. Hypoxia was induced by placing the rats in an altitude chamber (5,500 m) for 4 weeks. Both the renal efferent nervous activity (RENA) and the renal afferent nervous activity (RANA) were recorded simultaneously throughout the experimental period. It was found that the responses of RENA and RANA to an intravenous saline infusion (10 ml, 10 min) were significantly different between the sea level (SL) control and HA rats. In SL rats, a depression of RENA was found; the depressed RENA had not recovered 80 min after cessation of the saline infusion. In HA rats, an initially depressed RENA was also found; however, it returned to the control level within 10 min following the cessation of saline infusion. RANA enhanced twice a few minutes after saline loading in SL rats; however, the changes of RANA in HA rats were not significant. In both groups of rats, whether renally denervated or intact, the amount of excretory urine and sodium after saline loading was unchanged. The renal norepinephrine levels were also measured by a high-pressure liquid chromatography system in both groups of rats, and it was found that the renal norepinephrine content of the HA rats was significantly higher than in the SL rats. From these results, it was concluded that the renal nervous response to volume expansion is different in anesthetized chronic hypoxic rats; however, in spite of the impaired renal nervous activity, other regulatory systems still work successfully to maintain the renal function at a steady state.

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          Author and article information

          Journal
          KBR
          Kidney Blood Press Res
          10.1159/issn.1420-4096
          Kidney and Blood Pressure Research
          S. Karger AG
          1420-4096
          1423-0143
          1995
          1995
          11 November 2008
          : 18
          : 3
          : 153-160
          Affiliations
          Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan, ROC
          Article
          173912 Renal Physiol Biochem 1995;18:153–160
          10.1159/000173912
          7542795
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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