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      Pathology of childhood rhabdomyosarcoma: A consensus opinion document from the Children's Oncology Group, European Paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe

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          Abstract

          <p class="first" id="d6056345e190">The diagnosis and classification of rhabdomyosarcoma (RMS) has undergone several shifts over the last 30 years. While the main diagnostic categories remained the same, changes in the histologic criteria necessary for diagnosis, as well as varied reliance on immunohistochemical and molecular data over time, have created confusion, particularly regarding how these shifts impacted risk stratification and enrollment onto clinical trials. The goal of this report is to review the evolution and current status of RMS diagnosis, focusing on diagnostic criteria in the Children's Oncology Group (COG), the European Paediatric Soft Tissue Sarcoma Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS). In addition, we emphasize research tools used to classify RMS and address biological questions within current clinical trials run by each group. The INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT) initiative will maximize potential to optimize risk stratification by recognizing and accounting for differences in historical data and current practices. </p>

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          Contributors
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          Journal
          Pediatric Blood & Cancer
          Pediatr Blood Cancer
          Wiley
          1545-5009
          1545-5017
          March 2021
          December 11 2020
          March 2021
          : 68
          : 3
          Affiliations
          [1 ]Department of Laboratories Seattle Children's Hospital Seattle Washington
          [2 ]Department of Paediatric Histopathology Royal Manchester Children's Hospital Manchester Foundation Trust Manchester UK
          [3 ]Section of Pediatric Pathology Department of Pathology University Hospital Bonn Bonn Germany
          [4 ]Department of Pediatrics Duke University School of Medicine Durham North Carolina
          [5 ]Department of Pharmacology &amp; Cancer Biology Duke University School of Medicine Durham North Carolina
          [6 ]Sarcoma Molecular Pathology Team Divisions of Molecular Pathology and Cancer Therapeutics The Institute of Cancer Research London UK
          [7 ]Division of Pediatric Hematology and Oncology Department of Pediatric and Adolescent Medicine University Medical Center Freiburg University of Freiburg Freiburg Germany
          [8 ]Klinikum Stuttgart Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology) Stuttgart Germany
          [9 ]Cancer and Blood Disorders Center Seattle Children's Hospital and Fred Hutchinson Cancer Research Center Department of Pediatrics University of Washington School of Medicine Seattle Washington
          [10 ]Dipartimento per la Salute della Donna e del Bambino University of Padova Padova Italy
          Article
          10.1002/pbc.28798
          33306276
          c9461ea7-3915-42b0-a30d-cf8f5481cd33
          © 2021

          http://onlinelibrary.wiley.com/termsAndConditions#vor

          http://doi.wiley.com/10.1002/tdm_license_1.1

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