Zinc supplementation induces CD4+CD25+Foxp3+ antigen-specific regulatory T cells and suppresses IFN-γ production by upregulation of Foxp3 and KLF-10 and downregulation of IRF-1.

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Abstract

The essential trace element zinc plays a fundamental role in immune function and regulation since its deficiency is associated with autoimmunity, allergies, and transplant rejection. Thus, we investigated the influence of zinc supplementation on the Th1-driven alloreaction in mixed lymphocyte cultures (MLC), on generation of antigen-specific T cells, and analyzed underlying molecular mechanisms.

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Author and article information

Journal

Journal ID (iso-abbrev): Eur J Nutr

Title: European journal of nutrition

Publisher: Springer Nature America, Inc

ISSN (Electronic): 1436-6215

ISSN (Print): 1436-6207

Publication date (Electronic): Aug 2017

Volume: 56

Issue: 5

Affiliations

[1 ] Faculty of Medicine, Institute of Immunology, RWTH Aachen University, University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.

[2 ] Faculty of Medicine, Institute of Immunology, RWTH Aachen University, University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany. LRink@UKAachen.de.