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      Effect of Pilocarpine in Ocular Hypotension

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          In patients with normal intraocular pressure (IOP), local ocular application of pilocarpine causes IOP elevation, reaching a maximum at 10–20 min, and a subsequent prolonged fall of IOP below the baseline. We have studied the effect of pilocarpine in normal subjects with low baseline IOP ( < 10 mm Hg). The initial rise was larger than in normotensive controls (21 vs. 12%) and the subsequent fall was of similar relative magnitude (20%) as that of normotensives. Lower baseline IOP values were associated with greater initial rises and smaller subsequent falls. The mechanisms that may explain the two phases of IOP response to the administration of pilocarpine are discussed.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          04 December 2009
          : 17
          : 2
          : 72-74
          Department of Physiology and Pharmacology, Department of Preventive and Social Medicine, Sackler School of Medicine, Tel Aviv University, Ramat Aviv; Department of Neurology, Ichilov Hospital, the MOR Institute for Medical Data and Maurice and Gabriela Goldscheger Eye Research Institute, Tel Aviv, Israel
          265353 Ophthalmic Res 1985;17:72–74
          © 1985 S. Karger AG, Basel

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