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      Synthetic biological approaches to optogenetically control cell signaling.

      1 , 2
      Current opinion in biotechnology
      Elsevier BV

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          Abstract

          Precise spatial and temporal control of cellular processes is in life sciences a highly sought-after capability. In the recent years, this goal has become progressively achievable through the field of optogenetics, which utilizes light as a non-invasive means to control genetically encoded light-responsive proteins. The latest optogenetic systems, such as those for control of subcellular localization or cellular decision-making and tissue morphogenesis provide us with insights to gain a deeper understanding of the cellular inner workings. Besides, they hold a potential for further development into biomedical applications, from in vitro optogenetics-assisted drug candidate screenings to light-controlled gene therapy and tissue engineering.

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          Author and article information

          Journal
          Curr. Opin. Biotechnol.
          Current opinion in biotechnology
          Elsevier BV
          1879-0429
          0958-1669
          Oct 2017
          : 47
          Affiliations
          [1 ] Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
          [2 ] Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany. Electronic address: wilfried.weber@biologie.uni-freiburg.de.
          Article
          S0958-1669(17)30048-4
          10.1016/j.copbio.2017.06.010
          28715701
          c97b9fc6-c252-4146-88fa-01c2c9784aad
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