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      IL-28, IL-29 and their class II cytokine receptor IL-28R.

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          Abstract

          Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.

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          Author and article information

          Journal
          Nat Immunol
          Nature immunology
          Springer Science and Business Media LLC
          1529-2908
          1529-2908
          Jan 2003
          : 4
          : 1
          Affiliations
          [1 ] ZymoGenetics, Inc., 1201 Eastlake Avenue E., Seattle, WA 98102, USA.
          Article
          ni873
          10.1038/ni873
          12469119
          c9842a8c-4c60-416c-b96c-be171439efeb
          History

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