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      IL-28, IL-29 and their class II cytokine receptor IL-28R.

      Nature immunology

      Amino Acid Sequence, Animals, COS Cells, Cloning, Molecular, Cytokines, Gene Expression, Humans, In Vitro Techniques, Interleukins, genetics, metabolism, Molecular Sequence Data, Protein Subunits, RNA, Receptors, Cytokine, chemistry, Recombinant Proteins, Sequence Homology, Amino Acid, Signal Transduction, Virus Diseases, immunology

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          Abstract

          Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.

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          Journal
          12469119
          10.1038/ni873

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