Three experiments investigating the patient M.S.'s semantic memory are reported. Experiments 1 and 2 involved a category-membership decision task, in which M.S. was asked to determine whether a noun was a member of a specified semantic category. His performance in Experiment 1 was impaired for nouns from living categories in comparison with nouns from nonliving categories, and this impairment was especially marked for nouns of low typicality. Experiment 2 demonstrated an equivalent pattern of very poor performance to nouns of low familiarity from living categories. In Experiment 3 the effect of a category label on lexical decision was examined, using category labels as primes preceding nouns or pronounceable nonwords. Facilitation from related category label primes was found for typical and untypical members of living and nonliving semantic categories. These findings demonstrate that M.S. has impaired knowledge of the structure of living semantic categories when explicit access to this information is required (Experiments 1 and 2), but that some form of preserved category structure can be demonstrated in tasks which assess this implicitly (Experiment 3).