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      Bed Nucleus of the Stria Terminalis Subregions Differentially Regulate Hypothalamic–Pituitary–Adrenal Axis Activity: Implications for the Integration of Limbic Inputs

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          Abstract

          Limbic and cortical neurocircuits profoundly influence hypothalamic–pituitary–adrenal (HPA) axis responses to stress yet have little or no direct projections to the hypothalamic paraventricular nucleus (PVN). Numerous lines of evidence suggest that the bed nucleus of the stria terminalis (BST) is well positioned to relay limbic information to the PVN. The BST comprises multiple anatomically distinct nuclei, of which some are known to receive direct limbic and/or cortical input and to heavily innervate the PVN. Our studies test the hypothesis that subregions of the BST differentially regulate HPA axis responses to acute stress. Male Sprague Dawley rats received bilateral ibotenate lesions, targeting either the principal nucleus in the posterior BST or the dorsomedial/fusiform nuclei in the anteroventral BST. Posterior BST lesions elevated plasma ACTH and corticosterone in response to acute restraint stress, increased stress-induced PVN c- fos mRNA, and elevated PVN corticotropin-releasing hormone (CRH) and parvocellular arginine vasopressin (AVP) mRNA expression relative to sham-lesion animals. In contrast, anterior BST lesions attenuated the plasma corticosterone response and decreased c- fos mRNA induction in the PVN but did not affect CRH and parvocellular AVP mRNA expression in the PVN. These data suggest that posterior BST nuclei are involved in inhibition of the HPA axis, whereas the anteroventral BST nuclei are involved in HPA axis excitation. The results indicate that the BST contains functional subdomains that play different roles in integrating and processing limbic information in response to stress and further suggest that excitatory as well as inhibitory limbic information is funneled through these important cell groups.

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          Author and article information

          Journal
          J Neurosci
          J. Neurosci
          jneurosci
          J. Neurosci
          The Journal of Neuroscience
          Society for Neuroscience
          0270-6474
          1529-2401
          21 February 2007
          : 27
          : 8
          : 2025-2034
          Affiliations
          1Neuroscience Program and
          Departments of 2Psychiatry and
          3Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
          Author notes
          Correspondence should be addressed to Dennis C. Choi, University of Cincinnati, Psychiatry North, Building E, 2nd Floor, 2170 East Galbraith Road, Cincinnati, OH 45237-0506. choidc@ 123456ucmail.uc.edu
          Article
          PMC6673539 PMC6673539 6673539 3193689
          10.1523/JNEUROSCI.4301-06.2007
          6673539
          17314298
          Copyright © 2007 Society for Neuroscience 0270-6474/07/272025-10$15.00/0
          Categories
          Articles
          Behavioral/Systems/Cognitive
          Custom metadata

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