Pituitary-Gonadal Function in Three Relatives Presenting with Kallmann’s Syndrome

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The assumption that abnormalities exist in both the pituitary and gonads was tested in 3 familial cases of Kallmann’s syndrome, 2 brothers, aged 16 and 17 years, and their cousin, aged 26 years. Serial serum and urinary LH and FSH titers were measured after subcutaneous administration of 100 µg LRH and in the 2 brothers after a second test using 400 µg LRH. Serum testosterone and estradiol were estimated before and 60 and 90 min after LRH and also before and on the 3rd and 4th day after daily administration of 5,000 IU of hCG for 3 days. Prolactin was also measured in blood samples of all LRH tests and found normal in 2 cases and increased in 1. Tomograms of the pituitary fossa were normal in this patient. With all procedures used, a distinct stimulatory effect on the pituitary and the testes failed to appear in the patients of the present study.

Related collections

Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1980

Publication date (Print): 1980

Publication date (Electronic): 25 November 2008

Volume: 12

Issue: 2

Pages: 79-86

Affiliations

Endocrine Department, Alexandra Hospital, and Department of Pharmacology, University of Athens, Athens

Article

Publisher ID: 179107 Other ID: Horm Res 1980;12:79–86

DOI: 10.1159/000179107

PubMed ID: 6769771

SO-VID: c99534c8-873b-4726-bcf9-e9452c7f1eda

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 29 December 1978

Date accepted : 25 June 1979

Page count

Pages: 8

Comments

Comment on this article

scite_