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      Cancer metastasis: building a framework.

      Cell

      Phenotype, pathology, Neoplastic Cells, Circulating, Neoplasms, Neoplasm Metastasis, Humans, Evolution, Molecular, Basement Membrane, Animals

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          Abstract

          Metastasis occurs when genetically unstable cancer cells adapt to a tissue microenvironment that is distant from the primary tumor. This process involves both the selection of traits that are advantageous to cancer cells and the concomitant recruitment of traits in the tumor stroma that accommodate invasion by metastatic cells. Recent conceptual and technological advances promote our understanding of the origins and nature of cancer metastasis.

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          Journal
          10.1016/j.cell.2006.11.001
          17110329

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