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Pharmacogenetics of ACE inhibitor-induced angioedema and cough: a systematic review and meta-analysis.
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Abstract
Angioedema and cough are the two most important adverse effects of ACE inhibitors (ACEIs). Evidence exists that ACEI-related angioedema/cough is partly genetically determined and several genes have been identified to play a role in the development of ACEI-related adverse effects.