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      Extraction and determination by liquid chromatography and spectrophotometry of naloxone in microparticles for drug-addiction treatment.

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          Abstract

          This paper discusses the development and validation of two analytical methods for the assay of naloxone in microparticles, as used in the therapy of opioid drug addiction (weaning). A UV-Vis spectrophotometric method is proposed to study drug loading and drug release, due to its ease and simplicity of performance, while a high performance liquid chromatographic method is developed as a means of stability-indication. Both analytical procedures were validated according to the International Committee for Harmonization (ICH) guidelines. Although the ranges and wavelengths were different for the two analytical methods, they were both found to be specific, linear, precise, and accurate under the determined conditions.

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          Author and article information

          Journal
          J Sep Sci
          Journal of separation science
          1615-9306
          1615-9306
          Nov 2005
          : 28
          : 16
          Affiliations
          [1 ] Dept. Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Complutense University of Madrid, Spain. megil@farm.ucm.es
          Article
          16318204
          c9cf7869-1781-4bac-97cc-3476da3a1642

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