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      Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle

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      Bioinformatics

      Oxford University Press (OUP)

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          Abstract

          To understand the behaviour of complex biological regulatory networks, a proper integration of molecular data into a full-fledge formal dynamical model is ultimately required. As most available data on regulatory interactions are qualitative, logical modelling offers an interesting framework to delineate the main dynamical properties of the underlying networks. Transposing a generic model of the core network controlling the mammalian cell cycle into the logical framework, we compare different strategies to explore its dynamical properties. In particular, we assess the respective advantages and limits of synchronous versus asynchronous updating assumptions to delineate the asymptotical behaviour of regulatory networks. Furthermore, we propose several intermediate strategies to optimize the computation of asymptotical properties depending on available knowledge. The mammalian cell cycle model is available in a dedicated XML format (GINML) on our website, along with our logical simulation software GINsim (http://gin.univ-mrs.fr/GINsim). Higher resolution state transitions graphs are also found on this web site (Model Repository page).

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          Author and article information

          Journal
          Bioinformatics
          Bioinformatics
          Oxford University Press (OUP)
          1367-4803
          1460-2059
          July 27 2006
          July 15 2006
          July 27 2006
          July 15 2006
          : 22
          : 14
          : e124-e131
          Article
          10.1093/bioinformatics/btl210
          16873462
          c9d8bbc2-bbfa-4cbc-a329-d0470081d1ba
          © 2006

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