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      Dynamic reciprocity in the wound microenvironment.

      Wound Repair and Regeneration

      Animals, Biofilms, Cell Communication, Cell Movement, Cell Proliferation, Chronic Disease, Diabetic Foot, physiopathology, Extracellular Matrix, physiology, Hemostasis, Humans, Inflammation, Integrins, Intercellular Signaling Peptides and Proteins, Matrix Metalloproteinases, metabolism, Regeneration, Varicose Ulcer, Wound Healing, Wounds and Injuries

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          Abstract

          Here, we define dynamic reciprocity (DR) as an ongoing, bidirectional interaction among cells and their surrounding microenvironment. In this review, we posit that DR is especially meaningful during wound healing as the DR-driven biochemical, biophysical, and cellular responses to injury play pivotal roles in regulating tissue regenerative responses. Such cell-extracellular matrix interactions not only guide and regulate cellular morphology, but also cellular differentiation, migration, proliferation, and survival during tissue development, including, e.g., embryogenesis, angiogenesis, as well as during pathologic processes including cancer, diabetes, hypertension, and chronic wound healing. Herein, we examine DR within the wound microenvironment while considering specific examples across acute and chronic wound healing. This review also considers how a number of hypotheses that attempt to explain chronic wound pathophysiology may be understood within the DR framework. The implications of applying the principles of DR to optimize wound care practice and future development of innovative wound healing therapeutics are also briefly considered. © 2011 by the Wound Healing Society.

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          Author and article information

          Journal
          21362080
          3051353
          10.1111/j.1524-475X.2011.00673.x

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