Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.

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Abstract

Tryptophan (Trp) is catabolized by indoleamine 2,3-dioxygenase (IDO). Changes in Trp metabolism and IDO activity in chronic kidney disease (CKD) have not been widely studied, and the impact of haemodialysis is uncertain. Here we investigate Trp catabolism, IDO activity and the role of inflammation in moderate to very severe CKD and haemodialysis.

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Journal

Journal ID (iso-abbrev): Nephrol. Dial. Transplant.

Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1460-2385

ISSN (Print): 0931-0509

Publication date (Electronic): Jun 2009

Volume: 24

Issue: 6

Affiliations

[1 ] Department of Nephrology and Intensive Care, Charité University Medicine, Campus Virchow Clinic, Berlin, Germany. schefold@charite.de

Article

Publisher Item ID: gfn739

DOI: 10.1093/ndt/gfn739

PubMed ID: 19155537

SO-VID: ca27f4f6-47e8-4155-b6ef-aafed5fae384

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