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      CtBP2 Regulates TGFβ2-Induced Epithelial-Mesenchymal Transition Through Notch Signaling Pathway in Lens Epithelial Cells.

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          Abstract

          Epithelial-mesenchymal transition (EMT) of human lens epithelial cells (LECs) contributes to posterior capsule opacification (PCO). C-terminal binding protein 2 (CtBP2) has been reported to be essential in EMT and embryonic development. However, the function of CtBP2 in EMT of LECs is unknown. The goal of this study was to investigate the role of CtBP2 through Notch signaling in transforming growth factor β2 (TGFβ2)-induced EMT in LECs.

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          Author and article information

          Journal
          Curr. Eye Res.
          Current eye research
          Informa UK Limited
          1460-2202
          0271-3683
          August 2016
          : 41
          : 8
          Affiliations
          [1 ] a Eye Institute , Affiliated Hospital of Nantong University , Nantong , Jiangsu Province , China.
          Article
          10.3109/02713683.2015.1092554
          26681554
          ca28c87f-6f0e-40dc-890e-50b01fd421d6
          History

          Cataract,CtBP2 (C-terminal binding protein 2),EMT (epithelial–mesenchymal transition),PCO (posterior capsular opacification),TGFβ2

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