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      Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial.

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          Abstract

          The issue of whether regular use of an inhaled beta2-adrenergic agonist worsens airflow and clinical outcomes in asthma is controversial. Retrospective studies have suggested that adverse effects occur in patients with a genetic polymorphism that results in homozygosity for arginine (Arg/Arg), rather than glycine (Gly/Gly), at aminoacid residue 16 of the beta2-adrenergic receptor. However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          1474-547X
          0140-6736
          October 27 2004
          : 364
          : 9444
          Affiliations
          [1 ] Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. eisraelasst@partners.org
          Article
          S0140673604172735
          10.1016/S0140-6736(04)17273-5
          15500895
          ca29c505-3d0d-450f-bd00-7a4c79d86993
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