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      Physiological Significance of the Interleukin 1 Receptor Accessory Protein

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          Interleukin 1 receptor accessory protein (IL-1RAcP) is an essential signal-transducing component of the IL-1 receptor type I. The recent availability of IL-1RAcP-deficient (KO) mice allows to study the in vivo function of IL-1RAcP. Animals were injected intraperitoneally with rat recombinant IL-1β (200 ng/mouse), lipopolysaccharide (LPS, 5 µg/mouse), or subjected to 1-hour restraint stress. Neuroendocrine and immune parameters were measured 2 h after IL-1 or LPS injection or just after restraint. In wild-type controls, IL-1 and LPS activated the hypothalamic-pituitary-adrenal axis and increased plasma IL-6. In KO mice, the plasma levels of corticosterone and IL-6 increased after LPS, but not after rat recombinant IL-1β. The LPS-induced depression of the lymphoproliferation was similar in wild-type and KO mice. Finally, the 1-hour restraint was able to increase the plasma levels of corticosterone in KO mice. These results show that IL-1RAcP is essential for physiological activities of peripheral IL-1, as it was previously demonstrated for those of brain IL-1. However, using IL-1RAcP KO mice, we were unable to demonstrate a specific role of endogenous IL-1 during LPS-induced inflammation. Moreover, stress-induced activation of the hypothalamic-pituitary-adrenal axis may occur in the absence of the IL-1-transducing receptor, IL-1RAcP.

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          Most cited references 7

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          Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

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            Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice

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              Immobilization stress induces interleukin-1β mRNA in the rat hypothalamus


                Author and article information

                S. Karger AG
                February 2002
                15 February 2002
                : 9
                : 4
                : 225-230
                aLaboratoire de Neurocytochimie Fonctionnelle, Université de Bordeaux I, Talence, et bINSERM U 394 Neurobiologie Intégrative, Institut François-Magendie, Bordeaux, France
                49030 Neuroimmunomodulation 2001;9:225–230
                © 2002 S. Karger AG, Basel

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                Page count
                Figures: 4, References: 31, Pages: 6
                Original Paper


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