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      The Bcl2 family: regulators of the cellular life-or-death switch.

      Nature reviews. Cancer
      Animals, Apoptosis, Caspases, metabolism, Humans, Models, Molecular, Neoplasms, pathology, therapy, Protein Conformation, Proto-Oncogene Proteins c-bcl-2, chemistry

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          Abstract

          Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed by proteases called caspases. The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches.

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