Effects of an intra-ventricular assist device on the stroke volume of failing ventricle: Analysis of a mock circulatory system

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Abstract

BACKGROUND:

A novel intra-ventricular assist device (iVAD) was established as a new pulsatile assist device to address various disadvantages, such as bulky configuration and reduced arterial pulsatility, observed in conventional ventricular assist devices.

OBJECTIVE:

Analyzed the native left ventricular stroke volume (SV) after iVAD support in vitro.

METHODS:

The SV of iVAD was examined in a home-designed mock circulatory system (MCS) at different heart rates and drive pressures and the SV of a failure ventricle was examined with iVAD at 75, 90, 120 bpm and 120–180 mmHg drive pressure after iVAD support. Data pertaining to native left ventricular SV before and after iVAD support were compared.

RESULTS:

The native ventricular SV was improved by iVAD when its drive pressure (DP) was slightly greater than that of the mock system. Conversely, the native ventricular SV was decreased when DP was much greater than that (150 mmHg) of MCS. A high DP had a significant effect on SV.

CONCLUSIONS:

The proposed device improved the dysfunctional native left ventricular SV when DP of iVAD was slightly greater than that of MCS. However, iVAD reduced the SV when the drive pressure was greater than that of MCS.

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Most cited references 17

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Pregnancy in Women With a Mechanical Heart Valve: Data of the European Society of Cardiology Registry of Pregnancy and Cardiac Disease (ROPAC).

Iris M van Hagen, Jolien W Roos-Hesselink, Titia P E Ruys … (2015)

Pregnant women with a mechanical heart valve (MHV) are at a heightened risk of a thrombotic event, and their absolute need for adequate anticoagulation puts them at considerable risk of bleeding and, with some anticoagulants, fetotoxicity.

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Is Open Access

Evaluation of new suspension system for limb prosthetics

Hossein Gholizadeh, Noor Abu Osman, Arezoo Eshraghi … (2014)

Background Good prosthetic suspension system secures the residual limb inside the prosthetic socket and enables easy donning and doffing. This study aimed to introduce, evaluate and compare a newly designed prosthetic suspension system (HOLO) with the current suspension systems (suction, pin/lock and magnetic systems). Methods All the suspension systems were tested (tensile testing machine) in terms of the degree of the shear strength and the patient’s comfort. Nine transtibial amputees participated in this study. The patients were asked to use four different suspension systems. Afterwards, each participant completed a questionnaire for each system to evaluate their comfort. Furthermore, the systems were compared in terms of the cost. Results The maximum tensile load that the new system could bear was 490 N (SD, 5.5) before the system failed. Pin/lock, magnetic and suction suspension systems could tolerate loads of580 N (SD, 8.5), 350.9 (SD, 7) and 310 N (SD, 8.4), respectively. Our subjects were satisfied with the new hook and loop system, particularly in terms of easy donning and doffing. Furthermore, the new system is considerably cheaper (35 times) than the current locking systems in the market. Conclusions The new suspension system could successfully retain the prosthesis on the residual limb as a good alternative for lower limb amputees. In addition, the new system addresses some problems of the existing systems and is more cost effective than its counterparts.

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Pulsatile versus nonpulsatile flow during cardiopulmonary bypass: microcirculatory and systemic effects.

Michael O'Neil, Jennifer Fleming, Amit Badhwar … (2012)

Controversy exists regarding the optimal perfusion modality during cardiopulmonary bypass (CPB). Here we compare the effects of pulsatile versus nonpulsatile perfusion on microvascular blood flow during and after CPB. High-risk cardiac surgical patients were randomly assigned to have pulsatile (n=10) or nonpulsatile (n=10) flow during CPB. The sublingual microcirculation was assessed using orthogonal polarization spectral imaging. Hemodynamic and microvascular variables were obtained after anesthesia (baseline), during CPB, and post-CPB. Compared with baseline, a normal microcirculatory blood flow pattern was accomplished at all time points under pulsatile flow conditions. Peaking 24 hours postoperatively, a higher proportion of normally perfused microvessels occurred under pulsatile versus nonpulsatile flow (56.0%±3.9% vs 33.3%±4.1%; p<0.05). Concurrently, pulsatility resulted in a reduction in the prevalence of pathologic hyper-dynamically perfused vessels (6.0%±3.4% vs 19.6%±8.8%; p<0.05). Leukocyte adherence decreased relative to the nonpulsatile group both during and after CPB. Furthermore, peak lactate levels were reduced under pulsatile flow conditions postoperatively. Pulsatile perfusion is superior to nonpulsatile perfusion at preserving the microcirculation, which may reflect attenuation of the systemic inflammatory response during CPB. We suggest the implementation of pulsatile flow can better optimize microvascular perfusion, and may lead to improved patient outcomes in high-risk cardiac surgical procedures requiring prolonged CPB time. Copyright © 2012 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

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Author and article information

Journal

Journal ID (nlm-ta): Technol Health Care

Journal ID (iso-abbrev): Technol Health Care

Journal ID (publisher-id): THC

Title: Technology and Health Care

Publisher: IOS Press (Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands )

ISSN (Print): 0928-7329

ISSN (Electronic): 1878-7401

Publication date (Electronic, preprint): 4 May 2018

Publication date (Electronic, pub): 29 May 2018

Publication date (Electronic, collection): 2018

Volume: 26

Issue: Suppl 1 , Papers from the 6th International Conference on Biomedical Engineering and Biotechnology (iCBEB2017), 17–20 October 2017, Guangzhou, China

Pages: 471-479

Affiliations

[a ]Division of Advanced Manufacturing, Graduate School at Shenzhen, Tsinghua University , Shenzhen 518055, Guangdong, China

[b ]Cardiac Surgery Center, Beijing Anzhen Hospital, Capital Medical University , Beijing 100029, China

Author notes

[* ]Corresponding author: Xinghui Li, A-216, Tsinghua Campus, The University Town, Shenzhen 518055, Guangdong, China. Tel.: +86 13615541349; Fax: +86 755 26036618; E-mail: li.xinghuisz.tsinghua.edu.cn;XiaohaoWang,A-216,TsinghuaCampus,TheUniversityTown,Shenzhen518055,Guangdong,China.E-mail:xhwang@ 123456mail.tsinghua.edu.cn.

Article

Publisher ID: THC174752

DOI: 10.3233/THC-174752

PMC ID: 6004985

PubMed ID: 29758970

SO-VID: ca4696d9-c24e-4654-a53a-35548cc387f1

License:

This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).

Effects of an intra-ventricular assist device on the stroke volume of failing ventricle: Analysis of a mock circulatory system

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Abstract

BACKGROUND:

OBJECTIVE:

METHODS:

RESULTS:

CONCLUSIONS:

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Stroke MRI

Most cited references 17

Pregnancy in Women With a Mechanical Heart Valve: Data of the European Society of Cardiology Registry of Pregnancy and Cardiac Disease (ROPAC).

Evaluation of new suspension system for limb prosthetics

Pulsatile versus nonpulsatile flow during cardiopulmonary bypass: microcirculatory and systemic effects.

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