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      Changes in Blue Fluorescence Intensity and Coloration of Human Lens Protein with Normal Lens Aging and Nuclear Cataract


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          In the investigation reported here, intensity of blue fluorescence or coloration associated with human lens protein of nuclear cataract has been compared with that in the one of normal human. Blue fluorescence as well as coloration associated with proteins of aged normal lens and of nuclear cataractous lens appears to be localized in the nucleus which contains more water-insoluble protein than the cortex. In cortex and nucleus of normal lens, and in cortex of the cataractous lens, the blue fluorescence intensity of the lens protein seems to elevate linearly with an increase of percent urea-soluble protein, accompanied by a decrease of percent water-soluble protein. In nucleus of the cataractous lens, however, the fluorescence intensity tends to decrease significantly with an increase of percent urea-insoluble protein, mostly accompanied by a decrease of percent urea-soluble protein. Coloration of the lens protein tends to become deeper as human lens protein becomes insoluble. Particularly, in nucleus of the cataractous lens which contains urea-insoluble protein at a high concentration, the coloration seems to increase sharply as the content of urea-insoluble protein goes up. These results suggest the possibility that changes in the blue fluorescence intensity and coloration of human lens protein during aging of normal lens and development of nuclear cataract may be related to aggregation of the lens protein.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 8
          : 6
          : 456-463
          Department of Ophthalmology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo
          264854 Ophthalmic Res 1976;8:456–463
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          : 13 July 1976
          : 12 January 1977
          Page count
          Pages: 8

          Vision sciences,Ophthalmology & Optometry,Pathology
          Aging,Coloration,Water-soluble protein,Urea-soluble protein,Urea-insoluble protein,Blue fluorescence,Human lens,Nuclear cataract


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